柔性钯-银纳米线电极用于非酶葡萄糖检测

引用本文: 孟维琛, 王清翔, 李彦钊, 冯凌竹, 郎明非, 陈宏甡, 孙晶. 柔性钯-银纳米线电极用于非酶葡萄糖检测[J]. 分析化学, 2020, 48(3): 363-370. doi: 10.19756/j.issn.0253-3820.191672 shu

Citation: MENG Wei-Chen, WANG Qing-Xiang, LI Yan-Zhao, FENG Ling-Zhu, LANG Ming-Fei, CHEN Hong-Shen, SUN Jing. Flexible Palladium-silver Nanowire Electrode for Non-enzymatic Glucose Detection[J]. Chinese Journal of Analytical Chemistry, 2020, 48(3): 363-370. doi: 10.19756/j.issn.0253-3820.191672 shu

柔性钯-银纳米线电极用于非酶葡萄糖检测

孟维琛 ^1, ,
王清翔 ^1, ,
李彦钊 ^2, ,
冯凌竹 ^1, ,
郎明非 ^3, ,
陈宏甡 ^2, ,
孙晶 ^1,

1.
大连大学环境与化学工程学院, 大连 116622;
2.
大连大学附属中山医院, 大连 116622;
3.
大连大学医学院, 大连 116622
基金项目:
本文系国家自然科学基金项目（No.21505013）、辽宁省百千万人才项目（No.[2019]45）和大连市医学科学研究计划项目（Nos.1811106，1811121）资助

摘要: 糖尿病现已成为困扰全球人类健康的突出问题。微创检测血糖给患者带来不便和痛苦，而可穿戴无创血糖检测正成为研究和关注的热点。采用聚二甲基硅氧烷（Polydimethylsiloxane，PDMS）为柔性基底，以均匀涂布的银纳米线（Silver nanowires，AgNWs）为导电层，利用电化学方法将钯纳米粒子均匀沉积在AgNWs上，制备出不同沉积圈数的新型钯-银纳米线（Pd-AgNWs）柔性电极。以其作为工作电极，采用循环伏安法检测葡萄糖，发现沉积25圈钯的Pd-AgNWs电极在葡萄糖检测中具有最佳的电化学响应。优化了检测葡萄糖的实验条件，采用电流-时间法检测葡萄糖的两段线性范围分别为0.02~0.5 mmol/L和1~4 mmol/L，检出限为1 μmol/L （S/N=3），响应灵敏度为33.18 μA/cm²（mmol/L）。此电极表现出良好的重现性、稳定性和选择性，在无创唾液葡萄糖检测中具有良好的应用前景。

关键词:

English

Flexible Palladium-silver Nanowire Electrode for Non-enzymatic Glucose Detection

1.
College of Environmental and Chemical Engineering, Dalian University, Dalian 116622, China;
2.
Affiliated Zhongshan Hospital, Dalian University, Dalian 116622, China;
3.
College of Medicine, Dalian University, Dalian 116622, China
Received Date: 14 November 2019
Revised Date: 26 December 2019
Fund Project:
This work was supported by the National Natural Science Foundation of China (No. 21505013), the Liaoning BaiQian Wan Talents Program (No.[2019]45), and the Dalian Medical Science Research Project (Nos. 1811106, 1811121)

Abstract: Diabetes has become a prominent issue that threatens human's health. Minimally invasive blood glucose testing may cause inconvenience and pain to patients. Wearable non-invasive blood glucose testing is becoming a hot topic in the scientific and medical field. In this study, novel palladium-silver nanowires (Pd-AgNWs) flexible electrodes were prepared by electrochemical deposition of Pd nanoparticles on the electrode with polydimethylsiloxane (PDMS) as the substrate and AgNWs as the conductive layer. The nanoparticles were uniformly deposited on AgNWs and different Pd-AgNWs electrodes were made by changing Pd deposition cycles. By using them as the working electrodes, glucose was detected by cyclic voltammetry. It was found that the Pd-AgNWs electrode deposited with 25 cycles of palladium had the best results in the detection of glucose. The experimental conditions of glucose detection were optimized. The linear ranges of glucose were 0.02-0.5 mmol/L and 1-4 mmol/L when detecting glucose by current-time method. The detection limit was 1 μmol/L and the response sensitivity was 33.18 μA/(cm²(mmol/L)) (S/N=3). This electrode exhibited good reproducibility, stability, selectivity, as well as good response in detection of salivary glucose.

Key words:

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柔性钯-银纳米线电极用于非酶葡萄糖检测

English

Flexible Palladium-silver Nanowire Electrode for Non-enzymatic Glucose Detection

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