Citation: REN Fan-Dong, DING Xiao-Xue, CAI Fang, REN Da-Bing, YI Lun-Zhao, ZHANG Hong. Investigation of Metabolic Features of Patients with Coronary Heart Disease or Coronary Heart Disease-Type 2 Diabetes Mellitus Based on Ultra-High Performance Liquid Chromatography-High Resolution Mass Spectrometry[J]. Chinese Journal of Analytical Chemistry, ;2020, 48(1): 49-56. doi: 10.19756/j.issn.0253-3820.191618 shu

Investigation of Metabolic Features of Patients with Coronary Heart Disease or Coronary Heart Disease-Type 2 Diabetes Mellitus Based on Ultra-High Performance Liquid Chromatography-High Resolution Mass Spectrometry

1.
College of Agriculture and Food Science, Kunming University of Science and Technology, Kunming 650504, China;
2.
Department of Cardiology, Yunnan First People's Hospital, Kunming 650032, China

Received Date: 21 October 2019
Revised Date: 26 November 2019

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 21775058) and the Yunnan Provincial Applied Basic Research Project (Kun Medical Joint Project) (No. 2017FE468 (-169)).

Ultra-high performance liquid chromatography-quadrupole-orbitrap mass spectrometry was used in plasma metabolomics study of patients with coronary heart disease and coronary heart disease-type 2 diabetes mellitus. The aim was to explore the metabolic characteristics of coronary heart disease and coronary heart disease-type 2 diabetes mellitus, which would be useful for the optimization of clinical treatment plans based on metabolomics. A total of 78 endogenous metabolites were analyzed in plasma. On this basis, combined with partial least squares-discriminant analysis and variable importance projection, 20 characteristic metabolites were screened to distinguish healthy control from patients with coronary heart disease, 35 metabolites were screened for discrimination of patients with coronary heart disease and coronary heart disease-type 2 diabetes mellitus, 37 metabolites were screened to distinguish healthy control from patients with coronary heart disease-type 2 diabetes mellitus. Metabolic pathway analysis showed that amino acid metabolism played an important role in the physiological metabolism of these two types of patients, and fatty acid metabolism was likely to be associated with the complication of type 2 diabetes mellitus.
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