聚二乙炔囊泡的制备及其在医疗检测领域的应用

郝瑜佳 朱光明

引用本文: 郝瑜佳,  朱光明. 聚二乙炔囊泡的制备及其在医疗检测领域的应用[J]. 分析化学, 2020, 48(2): 164-173. doi: 10.19756/j.issn.0253-3820.191562 shu
Citation:  HAO Yu-Jia,  ZHU Guang-Ming. Advances in Fabrication of Polydiacetylene Vesicles and Their Applications in Medical Detection[J]. Chinese Journal of Analytical Chemistry, 2020, 48(2): 164-173. doi: 10.19756/j.issn.0253-3820.191562 shu

聚二乙炔囊泡的制备及其在医疗检测领域的应用

摘要: 聚二乙炔(Polydiacetylene,PDA)因具有独特的光学及电子特性而受到广泛关注。两亲性共轭二乙炔(Diacetylene,DA)单体在一定条件下可以自组装成囊泡结构,紫外线辐射后,经1,4-加成聚合得到聚合物PDA囊泡。PDA在环境刺激下经历颜色和荧光变化,而PDA囊泡的类细胞膜结构使其具有很好的仿生特性,因此PDA囊泡可以用于细菌、病毒、酶等的检测以及疾病诊断和药物控释。本文介绍了PDA囊泡传感系统的制备以及固相聚合和颜色变化的机理,综述了PDA囊泡传感系统在医疗检测领域的研究和应用进展,并对PDA囊泡传感系统存在的问题和未来发展方向进行了总结和展望。

English


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