快速蒸发-介质阻挡放电电离源的研制及其与小型化质谱仪的联用

引用本文: 葛赛金, 张英军, 朱雯飞, 吴辉, 白桦, 马强, 李晓旭. 快速蒸发-介质阻挡放电电离源的研制及其与小型化质谱仪的联用[J]. 分析化学, 2020, 48(1): 22-27. doi: 10.19756/j.issn.0253-3820.191550 shu

Citation: GE Sai-Jin, ZHANG Ying-Jun, ZHU Wen-Fei, WU Hui, BAI Hua, MA Qiang, LI Xiao-Xu. A Rapid Evaporation-Dielectric Barrier Discharge Ionization Source and Its Application in A Homemade Miniaturized Mass Spectrometer[J]. Chinese Journal of Analytical Chemistry, 2020, 48(1): 22-27. doi: 10.19756/j.issn.0253-3820.191550 shu

快速蒸发-介质阻挡放电电离源的研制及其与小型化质谱仪的联用

葛赛金 ^1, ,
张英军 ^1, ,
朱雯飞 ^1, ,
吴辉 ^1, ,
白桦 ^2, ,
马强 ^2, ,
李晓旭 ^1,

1.
苏州大学机电工程学院, 苏州 215021;
2.
中国检验检疫科学研究院, 北京 100176
基金项目:
本文系国家重点研发计划项目（No.2016YFF0203704）资助

摘要: 研制了小型化介质阻挡放电电离源（DBDI），将稀释或溶解于有机溶剂中的样品快速蒸发，以气溶胶的形态引入等离子体喷射区域，与实验室自制的小型化线形离子阱质谱仪联用，仪器整机体积为31.5 cm×27.3 cm×27.3 cm，重量仅18 kg。优化了载气流速和样品快速蒸发区域的温度，评估了仪器的检测限和稳定性等性能指标。实验结果表明，在选择离子存储条件下，可以检测出0.2 ng/mL咖啡因样品。通过连续进样并采集200张质谱图，计算得到样品离子强度的相对标准偏差（RSD）为11.1%。最后，分别检测了丙泊酚、精氨酸、SIPI5286和利血平等多种样品，得到了对应的质谱图。研制的快速蒸发小型化DBDI源与实验室自制的小型化线形离子阱质谱仪联用系统具有定性能力强、分析速度快、检测限低以及稳定性较高等特点，在现场实时检测领域具有良好的应用价值和发展前景。

关键词:

English

A Rapid Evaporation-Dielectric Barrier Discharge Ionization Source and Its Application in A Homemade Miniaturized Mass Spectrometer

1.
School of Mechanical and Electrical Engineering, Soochow University, Suzhou 215021, China;
2.
Institute of Inspection and Quarantine, Beijing 100176, China
Received Date: 12 September 2019
Revised Date: 05 November 2019
Fund Project:
This work was supported by the National Key Research and Development Program of China(No. 2016YFF0203704).

Abstract: A miniaturized dielectric barrier discharge ionization (DBDI) source assisted with a sample rapid evaporation platform was developed. With the DBDI source, the sample solution could be evaporated rapidly into aerosol state and then transferred to plasma ionization region, which improved the efficiency of sample transmission and ionization. The miniaturized DBDI source was coupled to a homemade miniaturized linear ion trap mass spectrometer which had a total volume of 31.5 cm×27.3 cm×27.3 cm and a weight of about 18 kg. In the experiment, the flow rate of carrier gas (He) and the temperature of sample rapid evaporation platform were optimized, and the limit of detection (LOD) and stability of the instrument were evaluated. Experimental results indicated that a LOD of 0.2 ng/mL (caffeine solution, mass selected storage, m/z 195) was achieved. The relative standard deviation (RSD) of the mass spectrum intensity was calculated to be 11.1%. Furthermore, various samples including propofol, arginine, SIPI5286 and reserpine were analyzed using the instrument. The combination of rapid evaporation assisted DBDI source and the homemade miniaturized linear ion trap mass spectrometer had the characteristics of strong qualitative ability, fast analytical speed, low limit of detection and high stability, and showed a great potential in the field of real-time and in-situ analysis.

Key words:

Miniaturization
/ Dielectric barrier discharge ionization
/ Rapid evaporation
/ Linear ion trap mass spectrometer
/ Limit of detection

1. [1]
  Yang S, Ding J, Zheng J, Hu B, Li J, Chen H, Zhou Z, Qian X. Anal. Chem.,2009,81(7):2426-2346
2. [2]
  Hendricks P I, Dalgleish J K, Shelley J T, Kirleis M A, McNicholas M T, Li L, Chen T C, Chen C H, Duncan J S, Boudreau F. Anal. Chem.,2014,86(6):2900-2908
3. [3]
  Huang G, Gao L, Duncan J, Harper J D, Sanders N L, Ouyang Z, Cooks R G. J. Am. Soc. Mass Spectrom.,2010,21:132-135
4. [4]
  Giannoukos S, Brkic B, Taylor S, France N. J. Am. Soc. Mass Spectrom.,2015,26:231-239
5. [5]
  Lawton Z E, Traub A, Fatigante W L, Fatigante L M, Mancias J, O'Leary A E, Hall S E, Wieland J R, Oberacher H, Gizzi M C, Mulligan C C. J. Am. Soc. Mass Spectrom.,2017,28(6):1048-1059
6. [6]
  Saha S, Mandal M K, Nonami H, Hiraoka K. Anal. Chim. Acta,2014,839:1-7
7. [7]
  Klute F D, Michels A, Schütz A, Vadla C, Horvatic V, Franzke J. Anal. Chem.,2016,88(9):4701-4705
8. [8]
  Gao L, Cooks R G, Ouyang Z. Anal. Chem.,2008,80(11):4026-4032
9. [9]
  Li X X, Zhang Y J, Ge S J, Qian J, Miao W. Analyst,2019,144:5127-5135
10. [10]
  Wells J M, Roth M J, Keil A D, Grossenbacher J W, Justes D R, Patterson G E, Barket D J. J. Am. Soc. Mass Spectrom.,2008,19:1419-1424
11. [11]
  March C, Karnes H T, Mclean A, Mukherjee P S. Biomed. Chromatogr.,2011,15:100-107
12. [12]
  Cooks R G, Ouyang Z, Takats Z, Wiseman J M. Science,2006,311(5767):1566-1570
13. [13]
  Zhan X, Zhao Z, Yuan X, Wang Q, Li D, Xie H, Li X, Zhou M, Duan Y. Anal. Chem.,2013,85(9):4512-4519
14. [14]
  HU Shun-Di, LIU Qi-Qiang, ZHAO Peng, HONG Huan-Huan, SHI Zhen-Zhi, ZHOU Zhen-Yu, WEN Lu-Hong. Chinese J. Anal. Chem.,2018,46(7):1017-1024 胡舜迪, 刘其强, 赵鹏, 洪欢欢, 史振志, 周镇宇, 闻路红.分析化学,2018,46(7):1017-1024
15. [15]
  HONG Huan-Huan, ZHAO Peng, NING Lu-Sheng, WEN Lu-Hong, XU Tie-Feng. Chinese J. Anal. Chem.,2017,45(10):1529-1534 洪欢欢, 赵鹏, 宁录胜, 闻路红, 徐铁锋.分析化学,2017,45(10):1529-1534
16. [16]
  CHU Yan-Qiu, XIAO Yu, LING Xing, DING Chuan-Fan. Chinese J. Anal. Chem.,2013,41(1):152-158 储艳秋, 肖育, 凌星, 丁传凡.分析化学,2013,41(1):152-158
17. [17]
  Xiao Y, Ding Z Z, Xu C S, Dai X H, Fang X, Ding C F. Anal. Chem.,2014,86(12):5733-5739
18. [18]
  Na N, Zhao M X, Zhang S C, Yang C D, Zhang X R. J. Am. Soc. Mass Spectrom.,2007,18:1859-1862

扫一扫看文章

计量

PDF下载量: 2
文章访问数: 35
HTML全文浏览量: 1

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

快速蒸发-介质阻挡放电电离源的研制及其与小型化质谱仪的联用

English

A Rapid Evaporation-Dielectric Barrier Discharge Ionization Source and Its Application in A Homemade Miniaturized Mass Spectrometer

计量

文章相关

通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处