神经递质检测方法的研究进展

万金霞 李毓龙

引用本文: 万金霞,  李毓龙. 神经递质检测方法的研究进展[J]. 分析化学, 2020, 48(3): 307-315. doi: 10.19756/j.issn.0253-3820.191548 shu
Citation:  WAN Jin-Xia,  LI Yu-Long. Recent Advances in Detection Methods for Neurotransmitters[J]. Chinese Journal of Analytical Chemistry, 2020, 48(3): 307-315. doi: 10.19756/j.issn.0253-3820.191548 shu

神经递质检测方法的研究进展

  • 基金项目:

    本文系北京市科委生命科学前沿创新培育项目(No.Z181100001318002)、国家重点基础研究发展规划(973计划)项目(No.2015CB856402)和国家自然科学基金项目(Nos.31671118,31371442)资助

摘要: 人的大脑中存在数以亿计的神经元,而神经元之间的信息传递主要依赖于通过化学突触发挥作用的神经递质。精确研究神经递质的动态变化对于理解神经系统的功能和研究神经系统疾病的发病机理等均具有重要意义。本文从技术原理、应用以及局限性等方面总结了近年来发展的一系列检测神经递质的方法,着重介绍了基于G蛋白偶联受体(G protein coupled receptor,GPCR)激活原理构建的可遗传编码荧光探针,此系列探针在特异性、灵敏度及时空分辨率方面均有优异的表现,同时,在活体动物实验中也表现出良好的信噪比。此外,此类探针的构建原理具有普适性,可用于开发检测不同神经递质的荧光探针。

English


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  • 收稿日期:  2019-09-11
  • 修回日期:  2019-12-10
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