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Citation: LI Yu-Ying, CUI Meng-Chao. Progress of Near-Infrared Fluorescent Probes for β-Amyloid Plaques in the Brain[J]. Chinese Journal of Analytical Chemistry, ;2019, 47(10): 1524-1536. doi: 10.19756/j.issn.0253-3820.191489 shu

Progress of Near-Infrared Fluorescent Probes for β-Amyloid Plaques in the Brain

Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China

Received Date: 10 August 2019
Revised Date: 5 September 2019

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 21571022)

β-Amyloid (Aβ) plaques as one of the important pathological hallmarks of Alzheimer's disease (AD) are regarded as key target for diagnosis of AD in early stage. In recent years, near-infrared fluorescence (NIRF) imaging has been developed rapidly, and has become a remarkable, noninvasive and inexpensive optical imaging tool for in vitro biological analysis, in vivo diagnosis and drug screening in animal models. In this review, we summarize current NIRF Aβ probes with sensing mechanism based on the intramolecular charge transfer (ICT) and outlined the influence of chemical structures on optical and biological properties, which is important for further development of high-sensitivity NIRF Aβ probes.
- Alzheimer's disease,
- β-Amyloid plaques,
- Near-infrared fluorescence imaging,
- Probes,
- Review
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