Citation: ZHANG Shuai, FENG Tao-Tao, ZHANG Li, ZHANG Mei-Ning. In Vivo Electrochemical Detection of Hydrogen Peroxide and Dopamine[J]. Chinese Journal of Analytical Chemistry, ;2019, 47(10): 1664-1670. doi: 10.19756/j.issn.0253-3820.191454 shu

In Vivo Electrochemical Detection of Hydrogen Peroxide and Dopamine

Department of Chemistry, Renmin University of China, Beijing 100872, China

Received Date: 28 July 2019
Revised Date: 28 August 2019

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 21874152).

Simultaneous analysis of hydrogen peroxide (H₂O₂) and dopamine (DA) in the central nervous system is of great significance and has great challenges. Herein, a ring-disk microelectrode for simultaneous electrochemical analysis of H₂O₂ and DA was developed. To selectively detect H₂O₂, the carbon fiber disk (CF_disk) electrode in the middle of the ring-disk microelectrode was electrochemically modified by Prussian blue (PB) and poly(2,3-dihydrothieno-1,4-dioxin) (PEDOT). The Au_ring on the periphery of the ring-disk microelectrode was used to detect DA. The ring-disk microelectrode exhibited sensitive response to H₂O₂ (linearity range:1-29 μmol/L) and DA (linearity range:0.5-25 μmol/L) with a detection limit of 0.4 μmol/L and 0.18 μmol/L, respectively. The ring-disk microelectrode was successfully used in measuring H₂O₂ and DA in rat brain. This method provided a new platform for the study of neurophysiology and pathology of H₂O₂ and DA.
- Hydrogen peroxide,
- Dopamine,
- In vivo,
- Microelectrodes,
- Electrochemical analysis
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