Citation: CHEN Chao-Yu, MA Yan, FANG Qun. Advances in Microfluidic Organ-on-a-Chip Systems[J]. Chinese Journal of Analytical Chemistry, ;2019, 47(11): 1711-1720. doi: 10.19756/j.issn.0253-3820.191423 shu

Advances in Microfluidic Organ-on-a-Chip Systems

CHEN Chao-Yu ^1, ,
MA Yan ² ,
FANG Qun ¹

1.
Institute of Microanalytical Systems, Department of Chemistry, Zhejiang University, Hangzhou 310058, China;
2.
Institute of Cancer and Basic Medicine(ICBM), Chinese Academy of Sciences;Cancer Hospital of the University of Chinese Academy of Sciences;Zhejiang Cancer Hospital, Hangzhou 310022, China

Received Date: 19 July 2019
Revised Date: 9 September 2019

Fund Project: This work was supported by the National Natural Science Foundation of China (Nos. 21435004, 21827806).

Organ-on-a-chip systems aim to build integrated microsystems to simulate human tissue and organ functions by utilizing the control ability of microfluidic chips to microfluids, cells and their micro-environment, for providing low-cost screening and research models close to in-vivo physiological and pathological conditions for evaluation of effectiveness and biosafety of drugs and vaccines, as well as biomedical research. In this review, the progress of organ-on-a-chip systems based on channels, chambers and membranes are introduced according to their structures and cell culturing modes.
- Organ-on-a-chip,
- Dynamic culture,
- Microfluidics,
- Review
1. [1]
2. [2]
3. [3]
4. [4]
5. [5]
6. [6]
7. [7]
8. [8]
9. [9]
10. [10]
11. [11]
12. [12]
13. [13]
14. [14]
15. [15]
16. [16]
17. [17]
18. [18]
19. [19]
20. [20]
21. [21]
22. [22]
23. [23]
24. [24]
25. [25]
26. [26]
27. [27]
28. [28]
29. [29]
30. [30]
31. [31]
32. [32]
33. [33]
34. [34]
35. [35]
36. [36]
37. [37]
38. [38]
39. [39]
40. [40]
41. [41]
42. [42]
43. [43]
44. [44]
45. [45]
46. [46]
47. [47]
48. [48]
49. [49]
50. [50]
51. [51]
52. [52]
53. [53]
54. [54]
55. [55]
56. [56]
57. [57]
58. [58]
59. [59]
60. [60]
61. [61]
62. [62]
63. [63]
64. [64]
65. [65]
66. [66]
67. [67]
68. [68]
69. [69]
70. [70]
71. [71]
72. [72]
73. [73]
74. [74]
75. [75]
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