Citation: WANG Xin, LI Ping, ZHANG Wen, TANG Bo. Recent Advances in Fluorescence Imaging of Bioactive Molecules in Neurons and in Vivo[J]. Chinese Journal of Analytical Chemistry, ;2019, 47(10): 1537-1548. doi: 10.19756/j.issn.0253-3820.191408 shu

Recent Advances in Fluorescence Imaging of Bioactive Molecules in Neurons and in Vivo

Key Laboratory of Molecular and Nano Probes, Ministry of Education;College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, China

Received Date: 19 July 2019
Revised Date: 20 August 2019

Fund Project: This work was supported by the National Natural Science Foundation of China (Nos. 21535004, 91753111, 21675105), the Key Research and Development Program of Shandong Province, China (No. 2018YFJH0502) and the National Major Scientific and Technological Special Project for "Significant New Drugs Development" (No. 2017ZX09301030004).

Brain possesses a unique chemical composition and reactivity. Bioactive molecules in brains including metal ions, reactive oxygen species, neurotransmitters and neurotransmitter hydrolases play multifarious and pivotal roles in the function of brain. These molecules keep steady-state concentrations for maintaining the structure and function of brain. However, the abnormal changes at bioactive molecular levels are associated with various brain diseases such as Parkinson's disease, Alzheimer's disease, depression, and so on. Therefore, to explore the concentration and regulation of those molecules in brains is particularly essential for revealing the mysteries of brains and understanding the occurrence and development of brain diseases. Fluorescence imaging is a powerful tool to track bioactive molecules in neurons and in brain because of its remarkable advantages, such as high temporal-spatial resolution, excellent biocompatibility and high sensitivity. In recent years, with the development of fluorescence imaging technology, a variety of fluorescent probes for brain and neurons imaging have been reported. In this review, we summarized the progress of molecular probes, nanoprobes and protein probes for detection of bioactive molecules in neurons and in brain. Furthermore, future research for fluorescence imaging was prospected.
- Fluorescent probe,
- Brain imaging,
- Bioactive molecule,
- Review
1. [1]
2. [2]
3. [3]
4. [4]
5. [5]
6. [6]
7. [7]
8. [8]
9. [9]
10. [10]
11. [11]
12. [12]
13. [13]
14. [14]
15. [15]
16. [16]
17. [17]
18. [18]
19. [19]
20. [20]
21. [21]
22. [22]
23. [23]
24. [24]
25. [25]
26. [26]
27. [27]
28. [28]
29. [29]
30. [30]
31. [31]
32. [32]
33. [33]
34. [34]
35. [35]
36. [36]
37. [37]
38. [38]
39. [39]
40. [40]
41. [41]
42. [42]
43. [43]
44. [44]
45. [45]
46. [46]
47. [47]
48. [48]
49. [49]
50. [50]
51. [51]
52. [52]
1. [1]
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3. [3]
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12. [12]
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17. [17]
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18. [18]
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