鸟嘌呤四链体在生化分析中的应用进展

引用本文: 刘卓靓, 陶呈安, 王建方. 鸟嘌呤四链体在生化分析中的应用进展[J]. 分析化学, 2020, 48(2): 153-163. doi: 10.19756/j.issn.0253-3820.191399 shu

Citation: LIU Zhuo-Liang, TAO Cheng-An, WANG Jian-Fang. Progress on Applications of G-quadruplex in Biochemical Analysis[J]. Chinese Journal of Analytical Chemistry, 2020, 48(2): 153-163. doi: 10.19756/j.issn.0253-3820.191399 shu

鸟嘌呤四链体在生化分析中的应用进展

1.
国防科技大学文理学院生物与化学系, 长沙 410073;
2.
湖南大学化学生物传感与计量学国家重点实验室, 长沙 410082
基金项目:
本文系国家自然科学基金项目（No.21705163）、湖南省科技创新计划项目（No.2019JJ50737）、国防科技大学校预研资助项目（No.ZK18-03-39）和湖南大学化学生物传感与计量学国家重点实验室开放基金项目（No.2017011）资助

摘要: 鸟嘌呤四链体（G-四链体）是一种特殊的核酸二级结构，它可与高铁血红素结合，形成具有过氧化物酶活性的核酶；也可增强特殊结构染料的荧光强度。G-四链体作为功能核酸中的一种，具有性质稳定、特异性好、功能多样等特点，被广泛应用于各种生化分析中。本文对近年来G-四链体在生化分析中的研究和应用进展进行了评述，对其应用前景进行了展望。

关键词:

English

Progress on Applications of G-quadruplex in Biochemical Analysis

1.
Department of Biology and Chemistry, College of Liberal Arts and Sciences, National University of Defense Technology, Changsha 410073, China;
2.
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China
Received Date: 13 July 2019
Revised Date: 13 November 2019
Fund Project:
This work was supported by the National Natural Science Foundation of China (No. 21705163), the Natural Science Foundation of Hunan Province, China (No. 2019JJ50737), the Research Project of the National University of Defense Technology (No. ZK18-03-39) and the Open Subject of State Key Laboratory of Chemo/Biosensing and Chemometrics (No. 2017011).

Abstract: G-quadruplex is a special secondary structure of nucleic acid. G-quadruplex can bind with hemin to form DNAzyme with peroxidase activity, and also it can enhance the fluorescence intensity of some dyes. As one of the functional nucleic acids, G-quadruplex is widely used in various biochemical analyses due to its high stability, specificity and flexibility. The application of G-quadruplex in biochemical analysis and its application prospects are briefly introduced.

Key words:

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1.
沈阳化工大学材料科学与工程学院沈阳 110142

鸟嘌呤四链体在生化分析中的应用进展

English

Progress on Applications of G-quadruplex in Biochemical Analysis

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