协同流动对台阶乳化生成Janus液滴的影响研究

引用本文: 连娇愿, 郑素霞, 许忠斌, 阮晓东. 协同流动对台阶乳化生成Janus液滴的影响研究[J]. 分析化学, 2020, 48(1): 57-65. doi: 10.19756/j.issn.0253-3820.191343 shu

Citation: LIAN Jiao-Yuan, ZHENG Su-Xia, XU Zhong-Bin, RUAN Xiao-Dong. Study on Co-flow Effect on Janus Droplet Generation Based on Step Emulsification[J]. Chinese Journal of Analytical Chemistry, 2020, 48(1): 57-65. doi: 10.19756/j.issn.0253-3820.191343 shu

协同流动对台阶乳化生成Janus液滴的影响研究

1.
浙江大学能源工程学院化工机械研究所, 杭州 310027;
2.
杭州职业技术学院, 杭州 310018;
3.
浙江大学流体传动及控制国家重点实验室, 杭州 310027
基金项目:
本文系国家自然科学基金项目（No.21676244）资助

摘要: 连续相协同流动可增加台阶乳化的通量和控制灵活性，对液滴微流控有重要影响。本研究搭建了多通道台阶乳化装置制备Janus液滴，研究协同流动对Janus液滴生成的影响。首先，制备并优化多通道台阶乳化芯片，实现了Janus液滴的稳定生成。其次，通过改变连续相和离散相的流量，研究了其对Janus液滴生成的影响。发现改变两相流量，Janus液滴直径和频率发生相应变化，但其生成稳定性不受影响：当连续相流量增大时，生成的Janus液滴直径减小，频率增加；当离散相流量增大时，生成的Janus液滴直径增大，频率亦增大。在本实验条件下，两组分Janus液滴直径可控制在638~1640 μm之间，产生频率可控制在0.02~2.2 Hz之间。在此基础上，制作了三组分液滴生成芯片，并成功制得了三组分液滴。通过改变两相流量发现，三组分液滴直径随流量增加的变化更大，说明协同流动作用对三组分液滴生成的影响更大。本研究采用台阶乳化方法实现了液滴大小可在线调控的二组分和三组分液滴制备，为化学化工和微量分析检测研究提供了依据和方法。

关键词:

English

Study on Co-flow Effect on Janus Droplet Generation Based on Step Emulsification

1.
Institute of Process Equipment, College of Energy Engineering, Zhejiang University, Hangzhou 310027, China;
2.
Hangzhou Vocational and Technical College, Hangzhou 310018, China;
3.
The State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou 310027, China
Received Date: 20 June 2019
Revised Date: 15 July 2019
Fund Project:
This work was supported by the National Natural Science Foundation of China (No. 21676244).

Abstract: Continuous phase co-flow can increase the throughput and control flexibility of step emulsification, and has an important effect on droplet microfluidic. This study built a multi-channel step emulsification device to generate Janus droplets and to study the effects of both continuous phase co-flow and dispersed phase flow on the generation of Janus droplets. Firstly, Janus droplets were successfully prepared by the device, and the generation stability was optimized by using glass capillaries instead of microcapillary film based on their different wall contact angles at the channel outlet. Secondly, the effect on the generation of Janus droplet was studied by changing the flows of the continuous and dispersed phases, respectively. The result showed that the Janus droplets generation stability was almost independent of the two phases flow rates. When the continuous phase co-flow rate increased, the resulted Janus droplet diameter decreased, and the generation frequency increased. The droplet diameter decreased by 61% with the co-flow rate increasing from 0.01 mL/h to 30 mL/h. When the flow rate of dispersed phase increased, both the diameter and generation frequency of the generated Janus droplet increased. The droplet diameter increased by 63% as the dispersed phase flow increased from 0.1 mL/h to 3.0 mL/h. Within the scope of this study, the diameter and the generation frequency of the two components Janus droplet could be controlled in 638-1640 μm and 0.02-2.2 Hz, respectively. In addition, three-component droplets were generated successfully and steadily by a three-component droplet generation chip which was prepared based on the two-component droplet generation device. By changing the two phase flow rates, the droplet diameter and frequency could also be tuned on-line. When the co-flow rate increased from 1 mL/h to 30 mL/h, the droplet diameter decreased by 45%, and when the dispersed phase flow increased from 0.1 mL/h to 5 mL/h, the droplet diameter increased by 89%. The generation frequencies increased accordingly. Additionally, it was found that the co-flow effect had a greater impact on the generation of three-component droplet due to the result that the three-component droplet diameter changed greater than the two-component droplet when changing both the continuous and dispersed phase flows. Therefore, in this study, two-component and three-component droplets were generated by co-flowing step emulsification, which could be controlled on-line by changing the co-flow rate. The results of this study provided a basis and method for micro and trace research of chemical and analysis industry.

Key words:

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协同流动对台阶乳化生成Janus液滴的影响研究

English

Study on Co-flow Effect on Janus Droplet Generation Based on Step Emulsification

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