Citation: SU Ying-Ying, LI Chun-Yan, LI Di. Progress in Membrane Fusion and Its Application in Drug Delivery[J]. Chinese Journal of Analytical Chemistry, ;2019, 47(12): 1871-1877. doi: 10.19756/j.issn.0253-3820.191280 shu

Progress in Membrane Fusion and Its Application in Drug Delivery

1.
School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, China;
2.
Department of Respiratory Medicine, The First Hospital of Jilin University, Changchun 130021, China

Received Date: 13 May 2019
Revised Date: 14 June 2019

Fund Project: This work was supported by the National Natural Science Foundation of China (Nos. 21675166, 21874046) and the Fundamental Research Funds for the Central Universities of China.

Membrane fusion plays an important regulatory role in the life activities of organisms. Membrane fusion in cells plays a role in promoting the operation of molecules in cells throughout the life cycle of an organism, and the fusion of viruses and cell membranes may sometimes mark the end of an organism's life. However, due to the complexity of living cells, the interpretation of biological research results is often ambiguous, so only a few protein structures on the membrane such as SNARE (soluble N-ethyl maleimide sensitive factor attachment protein receptors) protein family and its role in promoting membrane fusion have been gradually explored. At the same time, to better study the mechanism of membrane fusion, a simple artificial model system was established to simulate the biofilm fusion, for example, the biological model of membrane fusion was established by using liposomes modified by DNA strand and liposomes modified by coiled coil peptide. The mechanism of SNARE promoting membrane fusion and the establishment of DNA and curling helical mediated membrane fusion were reviewed in this paper.
- Membrane fusion,
- Soluble N-ethyl maleimide sensitive factor attachment protein receptors,
- DNA,
- Review
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沈阳化工大学材料科学与工程学院沈阳 110142