Citation: LIANG Jun-Yu, TONG Pei-Hong, LI Jian-Ping. Research and Application of Glycoprotein Sensors Based on Glycosyl Recognition[J]. Chinese Journal of Analytical Chemistry, ;2019, 47(9): 1283-1292. doi: 10.19756/j.issn.0253-3820.191270 shu

Research and Application of Glycoprotein Sensors Based on Glycosyl Recognition

College of Chemical and Bioengineering, Guilin University of Technology, Guangxi Key Laboratory of Electrochemical and Magnetochemical Function Materials, Guilin 541004, China

Received Date: 8 May 2019
Revised Date: 18 June 2019

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 21765006) and the Natural Science Foundation of Guangxi, China (No. 2015GXNSFFA139005).

Glycoprotein is a binding protein whose structure is mainly determined by the content of sugars and proteins and the peptide bonds to which it binds. The glycoproteins can be mainly classified into lectin, hormone, enzyme and immunoglobulin according to the clinical role in the medical field. Glycoproteins have a variety of biological functions and are of great significance in the medical and biological fields. To study the biological information related to glycoproteins, it is necessary to establish a highly sensitive and efficient analytical detection method for glycoproteins. The assay of glycoproteins includes separation and purification method, structural analysis, and content determination. The commonly used methods for determination of glycoproteins are mass spectrometry, chromatography-mass spectrometry, surface excimer resonance, enzyme-linked immunosorbent assay, etc. In recent years, in the detection of glycoproteins, the research and application of sensors have gradually increased. This paper briefly summarized the analysis methods of glycoproteins and reviewed the research and application of glycoprotein biosensors based on glycosyl recognition. The glycoprotein biosensors including electrochemical sensors, optical sensors and mass sensors were introduced in detail. The future development direction of glycoprotein sensors was prospected.
- Glycoprotein,
- Glycosyl,
- Sensors,
- Review
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