Citation: WANG Xiao-Fei, SHEN Yun-Wang, ZHU Jue, ZHANG Bo. Metabolomics Study of Rat Urine with Long Term Arsenic Exposure[J]. Chinese Journal of Analytical Chemistry, ;2019, 47(7): 1045-1053. doi: 10.19756/j.issn.0253-3820.181762 shu

Metabolomics Study of Rat Urine with Long Term Arsenic Exposure

College of Chemistry & Chemical Engineering, Xiamen University, Xiamen 361005, China

Received Date: 6 December 2018
Revised Date: 6 March 2019

Fund Project: This work was supported by the National Natural Science Foundation of China (Nos. 21475110, 21535007, J1310024), the China Postdoc Foundation (No. 2018M642572), the Xiamen Municipal Science and Technology Plan Project (No. 3502Z20173019) and the Fundamental Research Funds for Central Universities of China (No. 20720160051).

Long term inorganic arsenic exposure can cause many diseases and health damage, and the biological mechanism underneath remains unclear. Globally, over 200 million people are under the threat of arsenic pollution of drinking water. In this study, we performed metabolomics analysis of rat urine samples which were exposed to inorganic arsenic through drinking water for a long term. The results indicated that long-term arsenic exposure could cause significant urinary metabolome change, especially for the high-dose exposure groups. Totally 36 kinds of differential metabolites were identified, in which 14 were related with amino acid metabolism, including tryptophan, arginine, proline, lysine, β-alanine, cysteine, methionine, glycine, serine and threonine, and 11 were related with lipid metabolism, including sphingolipids and fatty acids. The expression and post-translational modifications of proteins were also influenced. Such biological process mutations are the key molecular indicators of arsenic toxicological mechanisms.
- Arsenic exposure,
- Metabolomics,
- Urine,
- Long-term exposure,
- Liquid chromatography-mass spectrometry
1. [1]
2. [2]
3. [3]
4. [4]
5. [5]
6. [6]
7. [7]
8. [8]
9. [9]
10. [10]
11. [11]
12. [12]
13. [13]
14. [14]
15. [15]
16. [16]
17. [17]
18. [18]
19. [19]
20. [20]
21. [21]
22. [22]
23. [23]
24. [24]
25. [25]
26. [26]
27. [27]
28. [28]
29. [29]
30. [30]
31. [31]
32. [32]
33. [33]
34. [34]
35. [35]
36. [36]
37. [37]
38. [38]
39. [39]
40. [40]
41. [41]
42. [42]
43. [43]
44. [44]
45. [45]
46. [46]
47. [47]
48. [48]
49. [49]
50. [50]
51. [51]
52. [52]
53. [53]
54. [54]
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