Citation: JIA Wei, ZHANG Rong, SHI Lin, ZHANG Feng, XU Xiu-Li, CHU Xiao-Gang. Construction of Non-Target Screening Method for Pesticides in Milk and Dairy Products Based on Mass Spectrometry Fracture Mechanism[J]. Chinese Journal of Analytical Chemistry, ;2019, 47(7): 1098-1105. doi: 10.19756/j.issn.0253-3820.181711 shu

Construction of Non-Target Screening Method for Pesticides in Milk and Dairy Products Based on Mass Spectrometry Fracture Mechanism

JIA Wei ^1, ,
ZHANG Rong ¹ ,
SHI Lin ¹ ,
ZHANG Feng ² ,
XU Xiu-Li ² ,
CHU Xiao-Gang ^1,2

1.
School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China;
2.
Chinese Academy of Inspection and Quarantine, Beijing 100123, China

Received Date: 11 November 2018
Revised Date: 31 March 2019

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 31801643).

A method for non-target screening of pesticide residues in dairy products by ultra-high performance liquid chromatography-hybrid quadrupole-Orbitrap mass spectrometry (UHPLC-Q-Orbitrap MS) was developed. A database of pesticide residue standards was established for the experimental application of data-dependent acquisition mass spectrometry technology. Subsequently, the fragmentation mechanism of eight classes of 100 pesticides was studied, and the characteristic fracture fragments of different classes of pesticides were obtained. By combining pesticide fragmentation with the pesticide residue standard database, a non-directional screening method based on data-independent acquisition mass spectrometry was developed. Finally, the established method was applied to the non-directional analysis of pesticide residues in 93 batches of pasteurized milk and ultra-high temperature instant sterilized milk. As a result, pre-undetected azoxystrobin (2.3 μg/kg) and chlorthiamide (6.1 μg/kg) were detected in the samples, with the relative standard deviations of 2.3% and 1.2%. The high-resolution non-target screening analysis method established here can provide effective technical means for rapid screening and identification of pesticides in dairy products.
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