Citation: LIU Ya-Hui, WANG Zhi-Juan, YAN Zheng, ZHANG Qing, MA Qiang, BAI Hua, LYU Qing. Determination of 58 Kinds of Fragrance Allergens in Plastic Toys by Dissolution Precipitation-Gas Chromatography-Tandem Mass Spectrometry[J]. Chinese Journal of Analytical Chemistry, ;2019, 47(1): 129-137. doi: 10.19756/j.issn.0253-3820.181460 shu

Determination of 58 Kinds of Fragrance Allergens in Plastic Toys by Dissolution Precipitation-Gas Chromatography-Tandem Mass Spectrometry

LIU Ya-Hui ^1,2, ,
WANG Zhi-Juan ² ,
YAN Zheng ¹ ,
ZHANG Qing ² ,
MA Qiang ² ,
BAI Hua ² ,
LYU Qing ²

1.
College of Chemistry & Environmental Science, Hebei University, Baoding 071002, China;
2.
Institute of Industrial and Consumer Product Safety, Chinese Academy of Inspection and Quarantine, Beijing 100176, China

Received Date: 13 July 2018
Revised Date: 6 October 2018

Fund Project: This work was supported by the National Key Research and Development Program of China (No.2016YFF0203702).

A method was developed for simultaneous determination of 58 kinds of fragrance allergens in acrylonitrile-butadiene-styrene (ABS) and polyvinyl chloride (PVC) plastic toys based on dissolution precipitation-gas chromatography tandem mass spectrometry (GC-MS/MS). Sample was dissolved by tetrahydrofuran, and precipitated by methanol, and then its supernatant was taken through a 0.22-μm filter membrane. After separated by DB-17MS column, the analytes were determined by tandem mass spectrometry in SRM mode, and then quantified by the external standard method. The study optimized the GC-MS parameters for determination of 58 analytes and further proved that the dissolution precipitation method had a high extraction rate by determining the recovery of the homemade positive sample. Its results showed that GC-MS/MS had strong anti-matrix background interference ability. Due to the existence of solvent effect and matrix effect, the matrix matching standard curve method should be used for quantitative analysis. The limits of quantification (LOQs) for different substances were 0.1-10 mg/kg, and the correlation coefficient (R²) was larger than 0.9926 in the linear range of 0.1-600 mg/kg. The recoveries of fragrances in ABS and PVC samples ranged from 76.9% to 129.6% and 70.3% to 126.5%, respectively. The relative standard deviations (RSD, n=6) ranged from 0.9% to 10.2% and 1.1% to 9.6%, respectively. Finally, 65 commercial toys were detected, and the contents of 10 fragrances ranged from 3.0 to 46.8 mg/kg. The method was simple, rapid, accurate, sensitive and low cost, and suitable for the detection of 58 fragrance allergens in plastic toys.
- Fragrance allergens,
- Dissolution-precipitation,
- Gas chromatography-tandem mass spectrometry,
- Plastic toys
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