Citation: LYU Yue-Guang, BAI Hua, LI Wen-Tao, YANG Jing-Kui, HE Yu-Jian, MA Qiang. Progress of Sonic-Spray Ionization Mass Spectrometry and Its Applications[J]. Chinese Journal of Analytical Chemistry, ;2019, 47(1): 1-12. doi: 10.19756/j.issn.0253-3820.181411 shu

Progress of Sonic-Spray Ionization Mass Spectrometry and Its Applications

LYU Yue-Guang ^1,2, ,
BAI Hua ¹ ,
LI Wen-Tao ¹ ,
YANG Jing-Kui ² ,
HE Yu-Jian ² ,
MA Qiang ¹

1.
Chinese Academy of Inspection and Quarantine, Beijing 100176, China;
2.
School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing 100049, China

Received Date: 20 June 2018
Revised Date: 28 October 2018

Fund Project: This work was supported by the National Key Research and Development Program of China (No. 2016YFF0203704).

Sonic-spray ionization (SSI) is one of the simplest and most easily implemented ionization techniques. It relies solely on a high-velocity stream of nebulizing gas coaxial to spray capillary for ion formation with no assistance of externally applied ionization energies (e.g., voltage, heating, ultraviolet radiation, laser beams, corona or glow discharges), which are normally required for other ionization techniques. Gaseous ions are produced at room temperature and under atmospheric pressure due to a statistically unbalanced distribution of charges in the tiny droplets by the pneumatic spray. SSI has been originally used as an atmospheric ion source interface for liquid chromatography-mass spectrometry (LC-MS). The results obtained with the SSI interface are similar to those obtained with electrospray ionization (ESI). The SSI can produce both positive and negative charged droplets duo to the ion concentration distribution model. This will be beneficial for high-throughput MS analysis. Ambient ionization has been developed for rapid and direct MS analysis of analytes in untreated samples in their native environment, and opens an exciting perspective on simplification of analysis procedures by creating ions outside the instrument. Based on the principle of SSI, researchers have developed desorption sonic-spray ionization (DeSSI) as a novel ambient ionization method. The high-velocity sonic spray facilitates matrix penetration, therefore providing more homogenous sampling and longer-lasting ion signals. DeSSI is later renamed to easy ambient sonic spray ionization (EASI), forming an acronym that makes a direct correlation to its easiness. After more than 20 years of development, sonic-spray based ionization methods have shown a broad range of applications in an extremely wide array of specialities. Ranging from both qualitative and quantitative analyses to mass spectrometry imaging, the technique has shown unprecedented simplicity, speed, robustness and ease of use. This review elucidates the ionization mechanism of sonic-spray based ionization methods and reviews the wide applications of sonic-spray based ionization in the fields of life sciences, food safety, forensic chemistry, reaction monitoring, etc.
- Sonic-spray ionization,
- Easy ambient sonic-spray ionization,
- Mass spectrometry,
- Review
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