Citation: Peng ZHANG, Xiao-Mei ZHAO. Synthesis, Crystal Structure and Bioactivity Evaluation of a Heterocyclic Compound[J]. Chinese Journal of Structural Chemistry, ;2020, 39(10): 1892-1897. doi: 10.14102/j.cnki.0254–5861.2011–2682 shu

Synthesis, Crystal Structure and Bioactivity Evaluation of a Heterocyclic Compound

Peng ZHANG ^, ,
Xiao-Mei ZHAO

School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046, China

Corresponding author: Peng ZHANG, peng_zhang11@126.com
Received Date: 2 December 2019
Accepted Date: 12 February 2020

Figures(5)

The heterocyclic compound 2-amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide (1), designed using 2-chloro-6-methylaniline (2) as the start material, was successfully obtained via multiple synthesis route and finally characterized by IR, ¹H NMR, and single-cystal X-ray crystallography. To select the suitable candidates for tissue regeneration, the induction activity of the compound on the dental pulp mesenchymal stem cells (DP-MSCs) was evaluated. Firstly, the DP-MSCs cells were isolated and the cell colon formation ability was measured after compound treatment with cell colony determination. After that, the RT-PCT assay was conducted and the relative expression level of the genes related with cell osteogenesis and proliferation was further detected.
- heterocycles,
- X-ray,
- DP-MSCs,
- RT-PCT assay
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沈阳化工大学材料科学与工程学院沈阳 110142