Citation: Huiping Sun, Zuoxi Li, Yu Gu, Chunxian Guo. A Review on the Progress of Metal-Organic Frameworks in Electrochemiluminescence Sensors[J]. Chinese Journal of Structural Chemistry, ;2022, 41(11): 221101. doi: 10.14102/j.cnki.0254-5861.2022-0126 shu

A Review on the Progress of Metal-Organic Frameworks in Electrochemiluminescence Sensors

  • Author Bio: Huiping Sun received her Ph.D. in analytical chemistry from Northwest University in 2021. Currently, she is a lecturer in the Institute of Materials Science and Devices, Suzhou University of Science and Technology, China. Her research interests are electrogenerated chemiluminescence biosensor and functional materials
    Zuoxi Li is a professor in Suzhou University of Science and Technology. He obtained his bachelor's degree and Ph.D. from Nankai University in 2004 and 2009, respectively. His research work is closely related to the application of MOFs and MOFs-derived nanomaterials in adsorption and separation, supercapacitor, rechargeable battery, and electrocatalysis
    Yu Gu is an associate professor in Suzhou University of Science and Technology. She got her Ph.D. from China Pharmaceutical University in 2016, and continued her postdoctoral research in College of Chemistry and Chemical Engineering, Nanjing University from 2016 to 2018. Her research interests include the development bioanalytical chemistry, including nano-biosensors, bioimaging, liquid biopsy and early screening for illnesses
    Chunxian Guo is a professor in the School of Materials Science and Engineering as well as Director of the Jiangsu Laboratory for Biochemical Sensing and Biochip, Suzhou University of Science and Technology. He received his Ph.D. in Chemical and Biomedical Engineering from Nanyang Technological University, Singapore in 2011. His research focuses on the surface and interface engineering of functional materials and the development of high-performance biosensors for early diagnosis of significant diseases
  • Corresponding author: Huiping Sun,
  • Received Date: 17 May 2022
    Accepted Date: 11 July 2022
    Available Online: 25 July 2022


  • Electrochemiluminescence (ECL) is a powerful technology that is the triple point of chemical, electronic, and optical technologies. The ECL-based sensors attract enormous attention due to the unifying of the advantages of electrochemical and optical sensors. The development of ultrasensitive, rapid, highly specific, and cost-effective ECL sensors for detecting substances with human health and life is critical. Metal-organic frameworks (MOFs) is a kind of molecular crystalline material regarded as a promising candidate for application in ECL sensors after its great improvement because of the improved MOFs with particular merits such as large surface area, tunable pore scale, structural diversity, superior conductivity, water stability, low toxicity, and good biocompatibility. In this review, we emphasize discussing the applications of MOFs for ECL sensing detection of varying targets that are related to human health and life, such as metal ions, small molecules, nucleic acids, proteins, bacteria, and viruses. Then, the relationship between ECL performance and MOFs characters is sprinkled in the discussion of the representative example. Finally, we provide the potential opportunities and challenges faced by MOFs in the realm of ECL sensors, as well as the future perspectives.
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