Citation: SUN Guo-Xiang, SHI Yan-Xia, ZHAI Zhi-Wen, SUN Zhao-Hui, WENG Jian-Quan, TAN Cheng-Xia, LIU Xing-Hai, LI Bao-Ju. Synthesis, Crystal Structure and Antifungal Activity of 2-((2-Fluorobenzyl)thio)-5-(pyridin-4-yl)-1,3,4-oxadiazole[J]. Chinese Journal of Structural Chemistry, ;2016, 35(12): 1855-1859. doi: 10.14102/j.cnki.0254-5861.2011-1352 shu

Synthesis, Crystal Structure and Antifungal Activity of 2-((2-Fluorobenzyl)thio)-5-(pyridin-4-yl)-1,3,4-oxadiazole

a.
School of Chemistry and Chemical Engineering, Yancheng Institute of Technology, Yancheng, Jiangsu 224051, China
b.
College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China
c.
Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing 100014, China

Corresponding author: LIU Xing-Hai, xhliu@zjut.edu.cn LI Bao-Ju, libj@caas.cn
Received Date: 5 July 2016
Accepted Date: 17 October 2016

Fund Project: Natural Science Foundation of Zhejiang Province LY16C140007program of Science and Technology of Jiangsu Province BY2014108-14

Figures(3)

The title compound 2-((2-fluorobenzyl)thio)-5-(pyridin-4-yl)-1,3,4-oxadiazole (C₁₄H₁₀FN₃OS) was synthesized, and its structure was confirmed by ¹H NMR, MS, elemental analyses and X-ray diffraction. It crystallizes in the monoclinic system, space group P2₁/n with a=11.541(16), b=8.226(12), c=13.683(19)Å, β=94.872(17)°, V=1294(3)Å³, Z=4 and R=0.0648 for 2198 observed reflections with I>2σ(I). The preliminary biological test shows that the title compound has good activity against Pythium ultimum with inhibitory to be 100%.
- oxadiazole compound,
- synthesis,
- crystal structure,
- antifungal activity
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