Citation: SUN Guo-Xiang, SHI Yan-Xia, ZHAI Zhi-Wen, SUN Zhao-Hui, WENG Jian-Quan, TAN Cheng-Xia, LIU Xing-Hai, LI Bao-Ju. Synthesis, Crystal Structure and Antifungal Activity of 2-((2-Fluorobenzyl)thio)-5-(pyridin-4-yl)-1,3,4-oxadiazole[J]. Chinese Journal of Structural Chemistry, ;2016, 35(12): 1855-1859. doi: 10.14102/j.cnki.0254-5861.2011-1352 shu

Synthesis, Crystal Structure and Antifungal Activity of 2-((2-Fluorobenzyl)thio)-5-(pyridin-4-yl)-1,3,4-oxadiazole

  • Corresponding author: LIU Xing-Hai, xhliu@zjut.edu.cn LI Bao-Ju, libj@caas.cn
  • Received Date: 5 July 2016

    Fund Project: Natural Science Foundation of Zhejiang Province LY16C140007program of Science and Technology of Jiangsu Province BY2014108-14

Figures(3)

  • The title compound 2-((2-fluorobenzyl)thio)-5-(pyridin-4-yl)-1,3,4-oxadiazole (C14H10FN3OS) was synthesized, and its structure was confirmed by 1H NMR, MS, elemental analyses and X-ray diffraction. It crystallizes in the monoclinic system, space group P21/n with a=11.541(16), b=8.226(12), c=13.683(19)Å, β=94.872(17)°, V=1294(3)Å3, Z=4 and R=0.0648 for 2198 observed reflections with I>2σ(I). The preliminary biological test shows that the title compound has good activity against Pythium ultimum with inhibitory to be 100%.
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