Citation: YANG Ming-Yan, ZHAO Wen, LIU Xing-Hai, TAN Cheng-Xia, WENG Jian-Quan. Synthesis, Crystal Structure and Antifungal Activity of 4-(5-((2,4-Dichlorobenzyl)thio)-4-phenyl-4H-1,2,4-triazol-3-yl)pyridine[J]. Chinese Journal of Structural Chemistry, ;2015, 34(2): 203-207. doi: 10.14102/j.cnki.0254-5861.2011-0481 shu

Synthesis, Crystal Structure and Antifungal Activity of 4-(5-((2,4-Dichlorobenzyl)thio)-4-phenyl-4H-1,2,4-triazol-3-yl)pyridine

1.
College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China

Received Date: 20 August 2014
Available Online: 21 October 2014
Fund Project: This project was supported by National Natural Science Foundation of China (No. 21002090) (No. 21002090) and the National Key Technologies R&D Program (2011BAE06B03-01) (2010R50018-06)

The title compound 4-(5-((2,4-dichlorobenzyl)thio)-4-phenyl-4H-1,2,4-triazol-3-yl)pyridine (C₂₀H₁₄Cl₂N₄S) was synthesized, and its structure was confirmed by ¹H NMR, MS, elemental analyses and X-ray diffraction. It crystallizes in the monoclinic system, space group P2₁/c with a=14.885(5), b=8.597(2), c=16.144(5)Å, β=114.505(4)°, V=1879.8(10)Å³, Z=8 and R=0.0320 for 3108 observed reflections with I>2σ(I). The preliminary biological test shows that the title compound has activities against Stemphylium lycopersici (Enjoji) Yamamoto, Fusarium oxysporum. sp. cucumebrium, and Botrytis cinerea with inhibitory to be 53.57%, 66.67% and 24.44%, respectively.
- 1,2,4-triazole,
- pyridine,
- synthesis,
- crystal structure,
- fungicidal activities
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