Citation: CHENG Xiao-Bo, CHENG Chang-Mei, WANG Ru-Ji, HAO Jian. Single-crystal Cultivation and Structure Analysis of Unstable 1-Azido-2-chloro-4-nitrobenzenes[J]. Chinese Journal of Structural Chemistry, ;2014, 33(12): 1801-1806. doi: 10.14102/j.cnki.0254-5861.2011-0286 shu

Single-crystal Cultivation and Structure Analysis of Unstable 1-Azido-2-chloro-4-nitrobenzenes

a.
a. Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China;
b.
b. Department of Chemistry, Tsinghua University, Beijing 100084, China;
c.
c. Department of Chemistry, Beijing University of Chemical Technology, Beijing 100092, China

Corresponding author: CHENG Chang-Mei,
Received Date: 18 March 2014
Available Online: 26 June 2014

The 1-azido-2-chloro-4-nitrobenzene was prepared by nucleophilic substitution between 2-chloro-4-nitro-1-(trifluoromethylsulfinyl)benzene and sodium azide, and its structure was characterized by NMR spectrum and X-ray single-crystal diffraction. It crystallizes in the monoclinic system, space group P2₁/n, Z=8 and M_r=198.57. A cultivation process of the single crystal of unstable aryl azide was provided. The group of trifluoromethyl sulfinyl was found for the first time to be a new excellent leaving group of aromatic nucleophilic substitution reactions.
- 1-azido-2-chloro-4-nitrobenzene,
- aromatic nucleophilic substitution,
- X-ray single-crystal diffraction,
- trifluoromethylsulfinyl
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