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Citation: ZHANG Wei, YANG Li-qun, MENG Shu, LI Jian-xin, JIN Ying, YI Dong-xu. Preparation of Biodegradable Gestodene Sustained-release Implants and Drug Release in Vitro[J]. Polymer bulletin, ;2016, 0(7): 78-81. doi: 10.14028/j.cnki.1003-3726.2016.07.010 shu

Preparation of Biodegradable Gestodene Sustained-release Implants and Drug Release in Vitro

1.
Liaoning Research Institute of Family Planning, Shenyang 110031, China

Corresponding author: ZHANG Wei,
Received Date: 3 December 2015
Available Online: 15 March 2016
Fund Project: 国家自然科学基金(No.51503093) (No.51503093)辽宁省科学事业公益研究基金(No.2015001007) (No.2015001007)辽宁省博士科研启动基金(No.201501116) (No.201501116)沈阳市科技攻关项目(F16-205-1-37) (F16-205-1-37)

The gestodene sustained-release implants were prepared by twin-screw extrusion process with poly(ε-caprolactone) as a carrier. The molecular weight was investigated by Gel permeation chromatography(GPC) and the structure of the implant was observed by Scanning electron microscopy(SEM) and the state of the drug dispersed in the poly(ε-caprolactone) was measured by Fourier transform infrared spectroscopy(FT-IR). The drug loading content and the accumulative release ratio were determined by Ultraviolet spectrophotometry(UV). The results showed that the molecular weight had no obvious change after extrusion. The drug loaded implants were fabricated successfully and the drug did not precipitate on the surface of the drug loaded implants. The drug loaded implant was a physical mixture of drug and carrier. The drug release profile was long-term sustained and fit the first order equation well in vitro(r²=0.9948).
- Gestodene;Poly(ε-caprolactone);Sustained-release implants;Drug release in vitro
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