像散位移显微镜的研制及教学设计——推荐一个化学测量学实验(微纳先进表征)

引用本文: 周丹, 刘心月, 郭子靖, 杨建平, 郭泽莹, 任卓尔, 俞娥, 潘婷, 任豆豆, 曾智聪. 像散位移显微镜的研制及教学设计——推荐一个化学测量学实验(微纳先进表征)[J]. 大学化学, 2026, 41(6): 196-203. doi: 10.12461/PKU.DXHX202511180 shu

Citation: Dan Zhou, Xinyue Liu, Zijing Guo, Jianping Yang, Zeying Guo, Zhuoer Ren, E Yu, Ting Pan, Doudou Ren, Zhicong Zeng. Development and teaching design of astigmatic displacement microscopy: a recommended experiment for chemical metrology (micro-nano advanced characterization)[J]. University Chemistry, 2026, 41(6): 196-203. doi: 10.12461/PKU.DXHX202511180 shu

像散位移显微镜的研制及教学设计——推荐一个化学测量学实验(微纳先进表征)

周丹 ^1, ,
刘心月 ^1, ,
郭子靖 ^1, ,
杨建平 ^1, ,
郭泽莹 ^1, ,
任卓尔 ^1, ,
俞娥 ^2, ,
潘婷 ^{1,
,} ,
任豆豆 ^{1,
,} ,
曾智聪 ^{1,
,}

1.
兰州大学化学化工学院, 天然产物化学全国重点实验室, 甘肃兰州 730000;
2.
化学国家级实验教学示范中心(兰州大学), 甘肃兰州 730000

通讯作者: 潘婷,Email:pant20@lzu.edu.cn; 任豆豆,Email:120220905140@lzu.edu.cn; 曾智聪,Email:zengzc@lzu.edu.cn

基金项目:
国家自然科学基金(22574070)；教育部化学“101 计划”——化学测量学实验课程建设项目；教育部第三批虚拟教研室建设试点——“101 计划”化学测量学实验课程虚拟教研室

摘要: 在现有的本科实验教学中，微纳表征常采用扫描探针显微技术、扫描电镜显微技术，而对于光学非接触式测量技术则存在空白。像散位移显微镜是一种基于像散测量的新技术，其具备光学非接触、扫描范围大、成像速度快和轴向纳米级分辨率等优势。为了将其引入化学“101计划”——化学测量学实验，本文自主研发了一款专为教学实验定制的像散位移显微镜仪器，并基于该仪器设计了一套完整的实验教学方案。本实验涉及“化学-光学-电子学-微纳表征”领域，通过开展“位移信号标定-三维成像-振动分析-膜厚测量”这四部分内容，激发学生对微纳表征前沿动态的思考，了解高精尖表征技术对于先进制造的重要性，并在动手实践过程中增强科学仪器自主国产化的信心，培养仪器类人才。

关键词:

English

Development and teaching design of astigmatic displacement microscopy: a recommended experiment for chemical metrology (micro-nano advanced characterization)

Dan Zhou ^1, ,
Xinyue Liu ^1, ,
Zijing Guo ^1, ,
Jianping Yang ^1, ,
Zeying Guo ^1, ,
Zhuoer Ren ^1, ,
E Yu ^2, ,
Ting Pan ^{1,
,} ,
Doudou Ren ^{1,
,} ,
Zhicong Zeng ^{1,
,}

1.
State Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, Gansu Province, China;
2.
National Demonstration Center for Experimental Chemistry Education (Lanzhou University), Lanzhou 730000, Gansu Province

Corresponding author: Ting Pan, ; Doudou Ren, ; Zhicong Zeng,

Received Date: 25 November 2025
Revised Date: 06 February 2026
Available Online: 12 May 2026

Abstract: In current undergraduate laboratory curricula concerning micro-nano characterization, scanning probe microscopy and scanning electron microscopy are predominantly employed, while non-contact optical measurement techniques remain underrepresented. Astigmatic displacement microscopy (ADM) represents an innovative technique based on astigmatism measurement, offering distinct advantages including non-contact operation, extensive scanning range, rapid imaging speed, and axial nanometer-scale resolution. To incorporate this advanced technology into the “101 Plan” chemical metrology experiments, we have independently developed a customized ADM instrument specifically designed for instructional purposes and established a comprehensive experimental teaching protocol. This experiment integrates interdisciplinary knowledge from chemistry, optics, electronics, and micro-nano characterization. Through four modular components—displacement signal calibration, three-dimensional imaging, vibration analysis, and film thickness measurement—the curriculum aims to stimulate students’ critical thinking regarding cutting-edge developments in micro-nano characterization, enhance their understanding of the significance of high-precision characterization technologies in advanced manufacturing, and foster confidence in domestic instrument innovation through hands-on practice, thereby cultivating specialized talent in instrumentation.

Key words:

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像散位移显微镜的研制及教学设计——推荐一个化学测量学实验(微纳先进表征)

通讯作者: 潘婷,Email:pant20@lzu.edu.cn; 任豆豆,Email:120220905140@lzu.edu.cn; 曾智聪,Email:zengzc@lzu.edu.cn

English

Development and teaching design of astigmatic displacement microscopy: a recommended experiment for chemical metrology (micro-nano advanced characterization)

Corresponding author: Ting Pan, ; Doudou Ren, ; Zhicong Zeng,

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中国化学会秘书处

像散位移显微镜的研制及教学设计——推荐一个化学测量学实验(微纳先进表征)

通讯作者: 潘婷,Email:pant20@lzu.edu.cn; 任豆豆,Email:120220905140@lzu.edu.cn; 曾智聪,Email:zengzc@lzu.edu.cn

English

Development and teaching design of astigmatic displacement microscopy: a recommended experiment for chemical metrology (micro-nano advanced characterization)

Corresponding author: Ting Pan, ; Doudou Ren, ; Zhicong Zeng,

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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