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Citation: Xin Lai, Ruiyao Lin, Siqin Lin, Ruiqi Han, Qi Li. “绿波协同向优而行”——苯佐卡因合成实验的改进[J]. University Chemistry, ;2026, 41(5): 368-379. doi: 10.12461/PKU.DXHX202511167 shu

“绿波协同向优而行”——苯佐卡因合成实验的改进

Xin Lai ¹ ,
Ruiyao Lin ² ,
Siqin Lin ² ,
Ruiqi Han ² ,
Qi Li ^2,,

1.
Graduate School, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, Fujian Province, China;
2.
School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, Fujian Province, China

Corresponding author: Qi Li, liqi@fjtcm.edu.cn
Received Date: 21 November 2025
Revised Date: 26 February 2026

本实验对“有机化学实验”“药物化学实验”中苯佐卡因的合成实验进行改进。在传统合成路线基础上，通过更换氧化剂为高锰酸钾，并采用四丁基溴化铵为相转移催化剂，在中性条件下进行氧化反应，降低对硝基苯甲酸合成过程中的危险性；更换酯化反应催化剂为硫酸氢钠一水合物并利用超声装置提高对硝基苯甲酸乙酯的合成效率；最后利用超声装置提高醋酸-铁粉还原反应的产率。实验结果表明，改进后路线相较于传统实验路线，总产率提高了82.2%、实验总时长缩短了35.3%、反应试剂种类减少、后处理更加简便。整个实验贯穿绿色化学概念，融合多元学科知识与技术，综合提升学生的职业胜任力，兼具教学意义与推广潜力。
- Benzocaine,
- Synthesis experiment,
- Green chemistry,
- Ultrasonic-assisted synthesis,
- Phase-transfer catalysis
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“绿波协同 向优而行”——苯佐卡因合成实验的改进

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“绿波协同向优而行”——苯佐卡因合成实验的改进