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Citation: Qinqi Zhang, Zhuoran Bi, Yi Zhong, Ziting Xu, Lanlan Chen. 双重信号放大功能核酸荧光探针用于水中抗生素的超灵敏检测[J]. University Chemistry, ;2026, 41(5): 448-454. doi: 10.12461/PKU.DXHX202511151 shu

双重信号放大功能核酸荧光探针用于水中抗生素的超灵敏检测

College of Chemistry, Fuzhou University, Fuzhou 350108, Fujian Province, China

Corresponding author: Lanlan Chen, llchen@fzu.edu.cn
Received Date: 20 November 2025
Revised Date: 27 February 2026

功能核酸探针具有高特异性、高亲和力、高稳定性、低成本等优势，本实验将分子识别与分子循环等科研思维通过设计实验和优化应用流程的方式引入本科实验教学中，设计了双重信号放大的功能核酸探针，以核酸适体作为识别单元，通过杂交链式反应与脱氧核酶放大，以硫黄素与G-四链体结合的荧光信号实现水中氯霉素的超灵敏检测。
- Nucleic acid aptamer,
- Hybridization chain reaction cycle,
- DNAzyme,
- Ultrasensitive detection,
- antibiotics
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