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Citation: Xinran Han, Jiaxin Li, Yuhan Kang, Qiongyou Wu. 虚实融合驱动的绿色杀菌剂苯醚唑酰胺创制实验设计[J]. University Chemistry, ;2026, 41(5): 422-429. doi: 10.12461/PKU.DXHX202511113 shu

虚实融合驱动的绿色杀菌剂苯醚唑酰胺创制实验设计

National Key Laboratory of Green Pesticide, Central China Normal University, Wuhan 430079, Hubei Province, China

Corresponding author: Qiongyou Wu, qywu@ccnu.edu.cn
Received Date: 20 November 2025
Revised Date: 27 February 2026

为响应绿色农药创制复合型人才培养的迫切需求，本实验以“贯通式研究”为理念，构建了“计算机辅助筛选-有机合成-生物活性评价”虚实融合实验教学模式。该模式不仅系统融合计算化学、有机化学与化学生物学等多学科内容，更将真实科研流程有机融入实验教学全过程，推动科研思维下沉教学一线，为拔尖创新人才培养提供了新范式。本实验以琥珀酸脱氢酶(SDH)为分子靶标，围绕新型创制杀菌剂苯醚唑酰胺的筛选与活性验证开展教学设计。通过分子对接与虚拟筛选，引导学生理解靶标导向的分子设计理念；通过目标化合物的合成与结构表征，锤炼学生的实验操作与结构解析能力；最后通过酶抑制活性与菌丝体抑制实验，实现从分子识别到生物功能验证的完整教学闭环，体现了“理论构建-实验验证-结果反馈”的科研逻辑链条。通过项目化实施与模块化组织，该实验有效培养学生的跨学科思维、创新意识与综合实践能力，构建了绿色农药创制人才培养与实验教学深度融合的实践平台。
- Virtual-physical integration,
- Green fungicide,
- Fenopyramide,
- Succinate dehydrogenase,
- Bioactivity
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