Citation: Ruilin He, Fengyi Wang, Zhikai Xia, Linling Zheng, Yue Liu. 球核酸的制备及DNA检测应用[J]. University Chemistry, ;2026, 41(5): 230-238. doi: 10.12461/PKU.DXHX202511108 shu

球核酸的制备及DNA检测应用

College of Basic Medical Sciences, Army Medical University, Chongqing 400038, China

Corresponding author: Linling Zheng, Yue Liu,
Received Date: 20 November 2025
Revised Date: 26 February 2026

溶胶是生物医学领域常用的纳米材料，其在生物传感、生物成像、生物医药等方面有广泛的应用。在现有溶胶基本性质研究实验基础上，进一步开展溶胶的修饰和应用实验对拓展医学生的溶胶前沿知识、深化理解溶胶的医学应用具有重要意义。球核酸是溶胶修饰和应用最为成熟和典型的代表。本文结合团队关于球核酸制备的创新研究成果，面向医学检验技术专业新创球核酸的制备及应用实验。该实验系统融合金溶胶的合成、球核酸的制备(即金溶胶的DNA修饰)和DNA检测应用，实验内容前沿新颖，且设计合理、层层递进，有利于激发学生实验探究兴趣。实验结果表明，该新创实验操作简单、无需大型仪器、绿色安全、可行性和重复性好，适合本科生实验教学。本实验项目以培养科学创新素养为导向，将理论知识与实际问题相结合，且具备一定的挑战度，有助于提升学生综合运用知识分析问题、解决问题的能力。
- Gold sol,
- Spherical nucleic acid,
- Preparation,
- Characterization,
- DNA detection
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