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Citation: Fengcheng Jia, Zixia Zheng, Fei Li, Huiqin Duan, Gang Wang. 串联S_NAr/Aldol缩合构建季碳稠合吲哚啉[J]. University Chemistry, ;2026, 41(5): 190-197. doi: 10.12461/PKU.DXHX202511104 shu

串联S_NAr/Aldol缩合构建季碳稠合吲哚啉

School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan 430205, Hubei Province, China

Corresponding author: Fengcheng Jia, fengcheng-jia@wit.edu.cn
Received Date: 17 November 2025
Revised Date: 26 February 2026

目前大学本科基础有机化学实验多为简单的单元反应，一锅法串联反应的实验项目较少。本实验以廉价易得的3-甲基-2-吲哚酮和2-氯-5-硝基苯乙酮为原料，设计了一个包含芳香亲核取代与Aldol缩合的串联反应，可以合成含季碳中心的2,3-稠合吲哚啉。本实验蕴含丰富的理论知识，具有操作简单、反应稳定和可重复性高等特点。
- Tandem cyclisation reaction,
- S_NAr reaction,
- Aldol condensation,
- Quaternary carbon-containing fused indoline
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串联SNAr/Aldol缩合构建季碳稠合吲哚啉

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串联S_NAr/Aldol缩合构建季碳稠合吲哚啉