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Citation: Xi Tan, Chunhong Chen, Lijia Leng, Yulong Zhang. 二苯甲烷制备实验改进研究与拓展[J]. University Chemistry, ;2026, 41(5): 159-169. doi: 10.12461/PKU.DXHX202511049 shu

二苯甲烷制备实验改进研究与拓展

College of Chemistry, Chongqing Normal University, Chongqing 401331, China

Corresponding author: Yulong Zhang, 20190040@cqnu.edu.cn
Received Date: 10 November 2025
Revised Date: 25 February 2026

羰基还原反应是有机化学课程教学中的重点内容。当前本科基础实验教学中主要通过具有中国特色的黄鸣龙还原方法实现。该实验在本科教学实施过程中暴露出水合肼试剂毒性大、高温副产物多、后处理操作难和实验安全性低等问题。针对上述问题，我们对二苯甲烷制备实验进行如下改进：1) 采用绿色安全的聚甲基氢硅氧烷(PMHS)-FeCl₃还原体系替代N₂H₄·H₂O-KOH；2) 将高温易释放有毒且刺激性气味物质的二聚乙二醇溶剂替换成稳定易处理的1,2-二氯乙烷；3) 反应温度可由140-195 ℃的高温降低到70 ℃；4) 反应时间由4 h缩减至1 h；5) 采用研磨+抽滤的后处理方法替代操作复杂且不安全的减压蒸馏。此外，通过引入薄层色谱及柱色谱，红外及核磁表征等环节，基于药物分子酮洛芬进行选择性脱氧还原实验，设计成8学时综合性创新实验，提高了学生化学综合素养的培养。
- Deoxygenative reduction,
- Wolff-Kishner-Huang Minlon-reduction reaction,
- Benzophenone,
- Green chemistry,
- Experimental improvement and innovation
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