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Citation: Liangling Tan, Chonghua Zhang, Xianjun Liu, Yiting Xu, Wanqiang Liu. 科教融合导向的化学综合实验设计——以铜离子特异性荧光探针的研发与应用为例[J]. University Chemistry, ;2026, 41(10): 316-325. doi: 10.12461/PKU.DXHX202510041 shu

科教融合导向的化学综合实验设计——以铜离子特异性荧光探针的研发与应用为例

College of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411100, Hunan Province, China

Corresponding author: Chonghua Zhang, chonghua1226@hnu.edu.cn
Received Date: 15 October 2025
Accepted Date: 24 November 2025

科教融合是培养学生创新能力、激发学生学习兴趣的重要途径。本文结合本实验室的科研成果，设计了一项以科教融合为导向的化学综合实验。即通过设计合成基于2-吡啶甲酸酯的反应型荧光探针THL-Cu，并借助探针的荧光及颜色变化进行铜离子的含量鉴定。该探针对铜离子表现出高灵敏度，检出限为0.2 μmol·L^-1，并具有特异性的荧光增强响应，增强倍数约15倍。通过将探针合成、标准曲线绘制、荧光光谱测定、铜离子含量分析、铜离子回收等过程结合，学生可掌握有机合成、仪器分析、数据处理等专业知识，并融合绿色化学理念。本实验通过科教融合，实现了知识、能力与思政教育的协同培养。
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