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Citation: Yuanyuan Zeng, Xiaoti Chang, Jingru Li, Qilin Wang. 骨架编辑策略：异喹啉到2-氨基-1-萘甲醛的转化[J]. University Chemistry, ;2026, 41(10): 309-315. doi: 10.12461/PKU.DXHX202510028 shu

骨架编辑策略：异喹啉到2-氨基-1-萘甲醛的转化

College of Chemistry and Molecular Sciences, Henan University, Kaifeng 475004, Henan Province, China

Corresponding author: Qilin Wang, wangqilin@henu.edu.cn
Received Date: 10 October 2025
Accepted Date: 26 December 2025

与传统官能团转化化学相比，骨架编辑策略可以实现一个复杂分子到另一个复杂分子的快速转化，从而实现结构多样性合成。但是，在本科教学中，无论是理论教学还是实验教学，都还未涉及到骨架编辑相关知识的传授。本实验将骨架编辑策略这一科研前沿领域引入到本科实验教学，通过形式上的“删氮加碳”过程，建立了一种异喹啉到萘甲醛转化的新方法。本实验融合了有机化学实验教学中的多个实验操作，具有反应时间短(1.5 h)、原料廉价易得、操作简单的优点。产物结构经核磁共振波谱、X-射线单晶衍射、高分辨质谱以及熔点进行表征确认。通过本实验，学生不仅了解了骨架编辑的定义、应用价值和合成挑战，还进一步加深了对Diels-Alder反应的理解，巩固了实验室常用的分离操作和分析手段。本实验有利于培养学生分析问题、解决问题的综合能力，有助于激发学生的科研兴趣，培养其创新能力。
- Skeletal editing,
- Diels-Alder cycloaddition,
- Rearrangement,
- Experimental teaching
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