Abstract: The disconnection between secondary and university chemistry education is a core bottleneck restricting the early cultivation of top-tier talents in chemistry. Based on the laws of chemistry education and the development needs of students, the College of Chemistry and Molecular Engineering, Peking University, takes “respecting the diversity of students’ development and constructing a progressive path for ability cultivation” as its core concept, and centers on the three-dimensional connection goals of “knowledge-ability-cognition” to build a relatively complete practical system for secondary-university chemistry education connection. With activities such as summer courses, seminar camps, experimental camps, and corporate study tours as carriers, this system has realized an educational closed loop covering interest guidance, foundation consolidation, ability advancement, and disciplinary cognition. Meanwhile, it provides middle school teachers with guidance on teaching methods and knowledge connection, helping them become a key link in connecting the two educational stages. This practical system offers a referable paradigm for breaking the barrier between secondary and university chemistry education and cultivating top-tier talents in basic disciplines.