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Citation: Xiaomei Ai, Muran Lin, Jinlan Zeng, Jiwei Ren. 可见光催化绿色合成二肽化合物[J]. University Chemistry, ;2026, 41(5): 358-367. doi: 10.12461/PKU.DXHX202510007 shu

可见光催化绿色合成二肽化合物

Xiaomei Ai ¹ ,
Muran Lin ¹ ,
Jinlan Zeng ¹ ,
Jiwei Ren ^1,2,,

1.
College of Chemistry and Chemical Engineering, Taishan University, Tai'an 271000, Shandong Province, China;
2.
School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, Shandong Province, China

Corresponding author: Jiwei Ren, renjiwei@tsu.edu.cn
Received Date: 9 October 2025
Revised Date: 6 February 2026

本文报道了一种可见光催化三苯基膦促进的脱氧酰胺化策略，用于二肽化合物的合成。以金属铱的配合物为催化剂，在蓝光照射下N-保护的氨基酸产生酰基自由基，和氨基酸酯发生偶联反应生成二肽，产物具有较高的产率和非常好的非对映选择性。实验具有试剂廉价易得、反应条件温和、操作简单安全、绿色高效、重现性好等优点，时间可控制在8学时内。
- Visible light catalysis,
- Dipeptide,
- Deoxygenative amidation,
- Iridium complex,
- Triphenylphosphine
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