Home

Citation: Xingyu Wang, Xijia Ren, Yulu Zhang, Yuewei Yang, Jingyan Yi, Yuan Li, Kai Guo. G蛋白偶联受体的生命叙事：从信号密码到健康卫士[J]. University Chemistry, ;2026, 41(10): 182-189. doi: 10.12461/PKU.DXHX202509101 shu

G蛋白偶联受体的生命叙事：从信号密码到健康卫士

Xingyu Wang ¹ ,
Xijia Ren ¹ ,
Yulu Zhang ² ,
Yuewei Yang ² ,
Jingyan Yi ³ ,
Yuan Li ⁴ ,
Kai Guo ^3,,

1.
Department of Medical Imaging, Southwest Medical University, Luzhou 640000, Sichuan Province, China;
2.
Clinical Medical College, Southwest Medical University, Luzhou 640000, Sichuan Province, China;
3.
School of Basic Medical Sciences, Southwest Medical University, Luzhou 640000, Sichuan Province, China;
4.
Editorial Department of Journal of Kunming University of Science and Technology, Kunming 650500, Yunnan Province, China

Corresponding author: Kai Guo, guokai@swmu.edu.cn
Received Date: 24 September 2025
Accepted Date: 20 November 2025

以第20届人体健康卫士先进集体评选陈述会作为拟人化叙事框架，以上届获奖团队代表(受体酪氨酸激酶团队)阿洛为主持人，本届候选团队代表(G蛋白偶联受体团队)阿吉为陈述者。通过阿洛和阿吉的对话，系统展开围绕G蛋白偶联受体的科普叙事。全文涵盖三大核心内容。机制解密：追溯G蛋白的发现历史和结构特征，详解G蛋白偶联受体与G蛋白的结合、解离，鸟苷三磷酸/鸟苷二磷酸交换，构象变化的动态信号调控机制；疾病攻坚：拟人化呈现了G蛋白偶联受体成员在糖尿病血糖调控、高血压血管舒张、哮喘炎症反应中的干预机制；感官探索：系统介绍了G蛋白偶联受体成员介导视觉、嗅觉、甜味、鲜味、苦味、痒觉的信号转导机制。文章通过拟人化叙事手法，全面介绍了与G蛋白偶联受体相关的生物化学、病理生理学知识，既严谨展现了基础前沿知识，又通过“人体健康卫士”的隐喻，传递了珍爱生命、护佑健康、无私奉献的价值观。
- Human Health Defender,
- G protein coupled receptor,
- G protein,
- Diabetes,
- Asthma,
- Hypertension,
- Sensory system
1. [1]
2. [2]
  G. Sebastiani, E. Ceccarelli, M.G. Castagna, F. Dotta, Best Pract. Res. Clin. Endocrinol. Metab. 2018, 32(2), 201.
3. [3]
  F. Zhang, I. Armando, P.A. Jose, C. Zeng, J. Yang, Hypertens. Res. 2024, 47(9), 2317.
4. [4]
  E.L. McDuffie, R.A. Panettieri, Jr., C.P. Scott, Respir. Res. 2024, 25(1), 295.
5. [5]
6. [6]
  G. Sanz, I. Leray, D. Grebert, S. Antoine, A. Acquistapace, A. Muscat, A. Boukadiri, L.M. Mir, Oncotarget 2017, 8(3), 4330.
7. [7]
  M. Rodriguez, W. Luo, J. Weng, L. Zeng, Z. Yi, S. Siwko, M. Liu, Oncogenesis 2014, 11(3), e114.
8. [8]
  V. Lyall, G.L. Heck, A.K. Vinnikova, S. Ghosh, T.H. Phan, R.I. Alam, O.F. Russell, S.A. Malik, J.W. Bigbee, J.A. DeSimone, J. Physiol. 2004, 558(1), 147.
9. [9]
  X. Li, Am. J. Clin. Nutr. 2009, 90(Suppl 3), 733.
10. [10]
  X. Li, L. Staszewski, H. Xu, K. Durick, M. Zoller, E. Adler, Proc. Natl. Acad. Sci. 2002, 99(7), 4692.
11. [11]
  G. Nelson, J. Chandrashekar, M.A. Hoon, L. Feng, G. Zhao, N.J. Ryba, CS. Zuker, Nature 2002, 416, 199.
1. [1]
  Sirui Xin , Jiayin Zhou , Kin Shing Chan . Smelling Disease: E-nose. University Chemistry, 2024, 39(9): 141-145. doi: 10.3866/PKU.DXHX202309051
2. [2]
  Jiamiao Zhao , Yun Zhou , Han Li , Xuejun Zhang , Liming Fan . 尿糖检测试纸的色彩密语. University Chemistry, 2026, 41(5): 430-437. doi: 10.12461/PKU.DXHX202511125
3. [3]
  Zhi Zheng , Feiyang Liu , Junlong Zhao . D-Amino Acids and Mirror-Image Proteins. University Chemistry, 2026, 41(2): 353-359. doi: 10.12461/PKU.DXHX202505017
4. [4]
  Yongjie ZHANG , Bintong HUANG , Yueming ZHAI . Research progress of formation mechanism and characterization techniques of protein corona on the surface of nanoparticles. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2318-2334. doi: 10.11862/CJIC.20240247
5. [5]
  Xinran Zhang , Siqi Liu , Yichi Chen , Qingli Zou , Qinghong Xu , Yaqin Huang . From Protein to Energy Storage Materials: Edible Gelatin Jelly Electrolyte. University Chemistry, 2025, 40(7): 255-266. doi: 10.12461/PKU.DXHX202408104
6. [6]
  Junjie Zhang , Chaochao Dong , Jinke Li , Jiawen Guo , Yingxin Shui , Yue Wang , Xinhua Duan . 共轭聚合物探针的设计及其对藻蓝蛋白的智能检测. University Chemistry, 2026, 41(5): 285-293. doi: 10.12461/PKU.DXHX202509114
7. [7]
  Zeyu XU , Anlei DANG , Bihua DENG , Xiaoxin ZUO , Yu LU , Ping YANG , Wenzhu YIN . Evaluation of the efficacy of graphene oxide quantum dots as an ovalbumin delivery platform and adjuvant for immune enhancement. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1065-1078. doi: 10.11862/CJIC.20240099
8. [8]
  Xinyi Hong , Tailing Xue , Zhou Xu , Enrong Xie , Mingkai Wu , Qingqing Wang , Lina Wu . Non-Site-Specific Fluorescent Labeling of Proteins as a Chemical Biology Experiment. University Chemistry, 2024, 39(4): 351-360. doi: 10.3866/PKU.DXHX202310010
9. [9]
  Qunlong Zhang , Jingyi Kang , Jingwen Wang , Tiancheng Tan , Zhaoyong Lu . Divergent total synthesis of sesquiterpene (hydro)quinone meroterpenoids dysideanones A and E–G. Chinese Chemical Letters, 2025, 36(3): 109915-. doi: 10.1016/j.cclet.2024.109915
10. [10]
  Xinxue Li . 普通化学G判据的图形教学法. University Chemistry, 2026, 41(10): 448-453. doi: 10.12461/PKU.DXHX202511015
11. [11]
  Kai Han , Guohui Dong , Ishaaq Saeed , Tingting Dong , Chenyang Xiao . Morphology and photocatalytic tetracycline degradation of g-C3N4 optimized by the coal gangue. Chinese Journal of Structural Chemistry, 2024, 43(2): 100208-100208. doi: 10.1016/j.cjsc.2023.100208
12. [12]
  Yang Liu , Leilei Zhang , Kaixuan Liu , Ling-Ling Wu , Hai-Yu Hu . Penicillin G acylase-responsive near-infrared fluorescent probe: Unravelling biofilm regulation and combating bacterial infections. Chinese Chemical Letters, 2024, 35(11): 109759-. doi: 10.1016/j.cclet.2024.109759
13. [13]
  Liang Ma , Zhou Li , Zhiqiang Jiang , Xiaofeng Wu , Shixin Chang , Sónia A. C. Carabineiro , Kangle Lv . Effect of precursors on the structure and photocatalytic performance of g-C3N4 for NO oxidation and CO2 reduction. Chinese Journal of Structural Chemistry, 2024, 43(11): 100416-100416. doi: 10.1016/j.cjsc.2024.100416
14. [14]
  Yanghanbin Zhang , Dongxiao Wen , Wei Sun , Jiahe Peng , Dezhong Yu , Xin Li , Yang Qu , Jizhou Jiang . State-of-the-art evolution of g-C3N4-based photocatalytic applications: A critical review. Chinese Journal of Structural Chemistry, 2024, 43(12): 100469-100469. doi: 10.1016/j.cjsc.2024.100469
15. [15]
  Haitao Wang , Lianglang Yu , Jizhou Jiang , Arramel , Jing Zou . S-Doping of the N-Sites of g-C₃N₄ to Enhance Photocatalytic H₂ Evolution Activity. Acta Physico-Chimica Sinica, 2024, 40(5): 2305047-0. doi: 10.3866/PKU.WHXB202305047
16. [16]
  Xuejiao Wang , Suiying Dong , Kezhen Qi , Vadim Popkov , Xianglin Xiang . Photocatalytic CO₂ Reduction by Modified g-C₃N₄. Acta Physico-Chimica Sinica, 2024, 40(12): 2408005-0. doi: 10.3866/PKU.WHXB202408005
17. [17]
  Zhimin Yuan , Xingling Zhao , Xianglin Zhu , Kaili Wang , Ya-Qian Lan , Zaiyong Jiang . Solar-driven hydrogen peroxide production on designed g-C₃N₄: Strategies, mechanisms, and perspectives. Chinese Chemical Letters, 2026, 37(6): 112572-. doi: 10.1016/j.cclet.2026.112572
18. [18]
  Na WU , Xue ZHANG , Wenyan NIU , Yujuan ZHANG , Tuoping HU . Ni-NiO@g-C₃N₄: Fabrication and performance for electrocatalytic methanol oxidation. Chinese Journal of Inorganic Chemistry, 2026, 42(6): 1289-1298. doi: 10.11862/CJIC.20250369
19. [19]
  Ming-Zhu Zhu , Ze-Jun Xu , Jiao-Zhen Zhang , Li-Zhi Shi , Zong-Xu Gao , Yi Li , Shuang-Zhi Yuan , Yan-Rong Ma , Ai-Xia Cheng , Hong-Xiang Lou . Haploides A–G: Diterpenoids featuring four new carbon skeletons via non-carbocation-driven skeletal diversification. Chinese Chemical Letters, 2026, 37(7): 111584-. doi: 10.1016/j.cclet.2025.111584
20. [20]
  Zhiwei Meng , Shasha Chen , Pingyu Yang , Yupeng Yan , Guanjie Jiang , Qin Zhang , Yang Li . g-C3N4-based S-scheme heterojunction photocatalyst and its application. Chinese Journal of Structural Chemistry, 2026, 45(6): 100889-100889. doi: 10.1016/j.cjsc.2026.100889

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(144)
HTML views(11)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Address：Zhongguancun North First Street 2,100190 Beijing, PR China Tel: +86-010-82449177-888

DownLoad: Full-Size Img PowerPoint

Return