Citation: Rong Chen, Yuyuan Wang, Jingyan Yi, Yuan Li, Kai Guo. 细胞化学重编程：时光机里的细胞精灵[J]. University Chemistry, ;2026, 41(9): 257-263. doi: 10.12461/PKU.DXHX202509042 shu

细胞化学重编程：时光机里的细胞精灵

Rong Chen ¹ ,
Yuyuan Wang ² ,
Jingyan Yi ² ,
Yuan Li ³ ,
Kai Guo ^2,,

1.
Clinical Medical College, Southwest Medical University, Luzhou 646000, Sichuan Province, China;
2.
School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, Sichuan Province, China;
3.
Editorial Department of Journal of Kunming University of Science and Technology, Kunming 650500, Yunnan Province, China

Corresponding author: Kai Guo, guokai@swmu.edu.cn
Received Date: 10 September 2025
Revised Date: 26 November 2025

以青年学子林默的梦境为叙事主线，讲述其在学术失利后邂逅化学诱导多能干细胞精灵CiPS-073，通过时空穿越与科学对话，系统梳理了化学诱导多能干细胞研究的关键突破。细胞精灵带领林默回溯约翰·戈登的非洲爪蟾核移植实验(体细胞分化逆转的开端)，山中申弥团队通过4种转录因子实现诱导多能干细胞(iPSC)的里程碑和隐忧，以及化学小分子替代转录因子的探索。详解化学重编程的分子机制，并重点展现我国邓宏魁团队的突破——利用表观重置剂等小分子组合，跨过胚外内胚层中间状态，显著缩短体细胞重编程时间。文中展望iPSC在神经退行性疾病、心梗修复、糖尿病及老年黄斑治疗中的潜力。通过与细胞精灵的对话，林默直观理解“程序错误”的进化意义，最终领悟科研失败的价值，醒来后以全新姿态投入研究。故事以“失败驱动创新”为核心，鼓励青年学子直面挫折，将科研困境转化为突破契机，兼具科学普及与人生哲理的双重启示。
- Chemically induced pluripotent stem cells,
- Transcription factors,
- Combination of chemical small molecules,
- Chemical reprogramming
1. [1]
  J.B. Gurdon, J. Embryol. Exp. Morphol. 1962, 10, 622.
2. [2]
  K. Takahashi, S. Yamanaka, Cell 2006, 126(4), 663.
3. [3]
  K. Takahashi, K. Tanabe, M. Ohnuki, M. Narita, T. Ichisaka, K. Tomoda, S. Yamanaka, Cell 2007, 131(5), 861.
4. [4]
  H. Kamao, M. Mandai, S. Okamoto, N. Sakai, A. Suga, S. Sugita, J. Kiryu, M. Takahashi, Stem Cell Rep. 2014, 2(2), 205.
5. [5]
  D. Huangfu, R. Maehr, W. Guo, A. Eijkelenboom, M. Snitow, A.E. Chen, D.A. Melton, Nat. Biotechnol. 2008, 26(7), 795.
6. [6]
  D. Huangfu, K. Osafune, R. Maehr, W. Guo, A. Eijkelenboom, S. Chen, W. Muhlestein, D.A. Melton, Nat. Biotechnol. 2008, 26(11), 1269.
7. [7]
  J. Shu, C. Wu, Y. Wu, Z. Li, S. Shao, W. Zhao, X. Tang, H. Yang, L. Shen, X. Zuo, et al., Cell 2013, 153(5), 963.
8. [8]
  P. Hou, Y. Li, X. Zhang, C. Liu, J. Guan, H. Li, T. Zhao, J. Ye, W. Yang, K. Liu, et al., Science 2013, 341(6146), 651.
9. [9]
  J. Guan, G. Wang, J. Wang, Z. Zhang, Y. Fu, L. Cheng, G. Meng, Y. Lyu, J. Zhu, Y. Li, et al., Nature 2022, 605(7909), 325.
10. [10]
  Y. Wang, F. Peng, Z. Yang, L. Cheng, J. Cao, X. Fu, H. He, R. Cai, W. Zeng, Y. Dong, et al., Nat. Chem. Biol. 2025, 21(7), 1030.
11. [11]
  G. Wang, Y. Wang, Y. Lyu, H. He, S. Liuyang, J. Wang, S. Sun, L. Cheng, Y. Fu, J. Zhu, et al., Cell Rep. 2023, 42(6), 112547.
12. [12]
  S. Liuyang, G. Wang, Y. Wang, H. He, Y. Lyu, L. Cheng, Z. Yang, J. Guan, Y. Fu, J. Zhu, et al., Cell Stem Cell 2023, 30(4), 450.
13. [13]
  Y. Jin, H. Kim, S. Min, Y.S. Choi, S.J. Seo, E. Jeong, S.K. Kim, H.A. Lee, S.H. Jo, J.H. Park, et al., Sci. Adv. 2022, 8(50), eabn5768.
14. [14]
  Y. Ma, H. Xie, X. Du, L. Wang, X. Jin, Q. Zhang, Y. Han, S. Sun, L. Wang, X. Li, et al., Cell Discov. 2021, 7(1), 12.
15. [15]
  P. Rivetti di Val Cervo, R.A. Romanov, G. Spigolon, D. Masini, E. Martín-Montañez, E.M. Toledo, G. La Manno, M. Feyder, C. Pifl, Y.H. Ng, et al., Nat. Biotechnol. 2017, 35, 444.
16. [16]
  D.-H. Lee, E.C. Lee, J.Y. Lee, M.R. Lee, J.-W. Shim, J.S. Oh, Biomedicines 2024, 12, 1350.
17. [17]
  Y. Liu, C. Wei, Y. Yang, Z. Zhu, Y. Ren, R. Pi, Eur. J. Pharmacol. 2024, 982, 176930.
18. [18]
  S. Wang, Y. Du, B. Zhang, G. Meng, Z. Liu, S.Y. Liew, R. Liang, Z. Zhang, X. Cai, S. Wu, et al., Cell 2024, 187(22), 6152.
19. [19]
  K. Zhang, Y. Wang, Q. An, H. Ji, D. Wu, X. Li, L. Suo, C. Zhang, X. Dong, Cell Prolif. 2025, 58(5), e13785.
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