Abstract: The Molecular Science and Engineering major is a science engineering composite talent training specialty jointly established by the College of Chemistry at Nankai University and the College of Chemical Engineering at Tianjin University. Since its official enrollment in 2003, the major has undergone 20 years of construction and development with more than 1000 graduates combining a broad and profound foundation in chemistry and chemical engineering. In 2020, Molecular Science and Engineering has been selected as the national first-class specialty construction site, becoming the professional benchmark for the cultivation of interdisciplinary talents. In order to meet the strategic and development needs of “promoting school enterprise cooperation and cultivating outstanding talents” in the new era, Molecular Science and Engineering further deepens undergraduate teaching reform and talent cultivation above science engineering composite talents. It combines basic science, applied science, practical production, and international advanced enterprise models, exploring the international composite talent cultivation mode of science engineering enterprises, to establish a “fully first-class” talent cultivation system that combines patriotism, solid professional foundation, excellent innovation ability, and international research and development experience.