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Citation: Yuxing Ji, Aizhi Wu, Quanzhou Wu, Xiaojun Zhao. 姜黄素/铜胶体粒子的构建与控释性能分析——推荐一个医学本科院校物理化学创新实验[J]. University Chemistry, ;2026, 41(9): 282-292. doi: 10.12461/PKU.DXHX202508051 shu

姜黄素/铜胶体粒子的构建与控释性能分析——推荐一个医学本科院校物理化学创新实验

School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong Province, China

Corresponding author: Yuxing Ji, jiyuxing@guzcm.edu.cn
Received Date: 15 August 2025
Revised Date: 30 September 2025

为促进药学专业本科生对胶体化学及化学动力学基础知识的理解和运用，同时改善传统物理化学实验教学缺乏创新性和吸引力的缺点。将姜黄素/铜胶体粒子的制备与药物释放动力学研究实验引入教学实验课程，旨在通过科教融合与思政元素相结合，提升学生综合运用理论知识和实验技能的能力。实验利用配位键和自组装技术合成良好分散性且粒径均匀的药物/金属胶体粒子。采用透射电子显微镜、纳米粒度及Zeta电位分析仪和紫外-可见分光光度计等技术表征胶体粒子的粒径、表面电荷、紫外-可见吸收峰等性质及其对pH药物可控释放的依赖性和自由基生成能力。这种开放式实验设计不仅增强了学生将理论与实践相结合的能力，还通过跨学科研究激发了学生的学习兴趣，实现了基础教学与科学训练的有机融合，为培养创新型制药人才提供了一种有效的方法。
- Colloidal nanoparticles,
- Curcumin,
- Drug release,
- Chemical kinetics equation
1. [1]
  A. Udepurkar, C. Devos, P. Sagmeister, F. Destro, P. Inguva, S. Ahmadi, E. Boulais, Y.F. Quan, R.D. Braatz, A.S. Myerson, ACS Nano 2025, 19, 21206.
2. [2]
  J. Soukar, N.A. Peppas, A.K. Gaharwar, Adv Sci. 2025, 12, e2411720.
3. [3]
4. [4]
5. [5]
  W. Wang, M.Q. Li, L.Z. Wang, L. Chen, B.-C. Goh, Cancer Lett. 2023, 570, 216332.
6. [6]
7. [7]
  C.F. Liu, M. Rokavec, Z.K. Huang, H.K. Hermeking, Cell Death Differ. 2023, 30, 1771.
8. [8]
9. [9]
  L.L. Chen, Q.Q. Shen, Y.J. Liu, Y.Q. Zhang, L.P. Sun, X.Z. Ma, N. Song, J.X. Xie, Signal Transduct. Target Ther. 2025, 10, 31.
10. [10]
  Y.M. Wang, Y.M. Chen, J.J. Zhang, Y.H. Yang, J.S. Fleishman, Y. Wang, J.H. Wang, J.C. Chen, Y.F. Li, H.Q. Wang, Drug Resist Updat. 2024, 72, 101018.
11. [11]
  F.-S. Yan, J.-L. Sun, W.-H. Xie, L. Shen, H.-F. Ji, Nutrients 2017, 10, 1146.
12. [12]
13. [13]
  X.-Q. Wang, W.J. Wang, M.Y. Peng, X.-Z. Zhang, Biomaterials 2021, 266, 12047
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