Citation: Baitong Wei, Rongxiu Zhu, Zhenghu Xu. 双环[1.1.0]丁烷合成策略的研究进展[J]. University Chemistry, ;2026, 41(9): 162-172. doi: 10.12461/PKU.DXHX202508027 shu

双环[1.1.0]丁烷合成策略的研究进展

School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, Shandong Province, China

Corresponding author: Rongxiu Zhu, Zhenghu Xu,
Received Date: 5 August 2025
Revised Date: 30 September 2025

双环[1.1.0]丁烷(Bicyclo[1.1.0]butane，BCB)是碳原子最少的桥环化合物之一，具有高环张力和独特反应性，是一类构建功能化小分子的重要有机物，在药物化学、合成化学等领域引发广泛关注。本文系统梳理了BCBs的主要合成策略，按反应类型将其归纳为取代反应、插入反应和重排反应三大类，涵盖了从经典方法到最新研究的代表性案例。各类合成方法展现出构建路径的多样性与策略设计的创新性，有助于激发学生的学习兴趣与结构思维。本文旨在作为教材知识与前沿研究之间的桥梁，为有机合成课程教学与科研训练提供参考与拓展素材，并通过精选的典型案例，帮助课堂教学实现难点突破与思维训练。
- Bicyclo[1.1.0]butane,
- Organic synthesis,
- Organic synthesis education
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