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Citation: Ziwen Lei, Mingyin Liu, Jiayi Shi, Yahan Shan, Qi Zhang. 当超分子二肽遇上酸碱指示剂：热响应水凝胶的智能可视化[J]. University Chemistry, ;2026, 41(8): 210-219. doi: 10.12461/PKU.DXHX202508014 shu

当超分子二肽遇上酸碱指示剂：热响应水凝胶的智能可视化

Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China

Corresponding author: Yahan Shan, Qi Zhang,
Received Date: 5 August 2025
Accepted Date: 30 September 2025

将苯酚红、溴甲酚氯等酸碱指示剂与小分子二肽Fmoc-FF构筑的水凝胶相结合，利用酸碱指示剂的变色特性探究多肽水凝胶的pH响应。同时也利用水凝胶的热响应性设计了一系列的科普互动实验。通过这些科普实验，旨在引导学生学习酸碱指示剂变色原理与水凝胶热响应原理的作用机制。此外，通过简单的实验验证，使学生能够将水凝胶的凝胶-溶液可逆相转变与直观的颜色变化相耦合，提升了科普实验的趣味性，并激发了实验者进一步利用这些性质开发更加个性化的艺术创作，探索科学之美。
- Supramolecular hydrogel,
- pH Indicator,
- Popular science experiment,
- Dipeptide self-assembly
1. [1]
  X. Du, J. Zhou, B. Xu, Chem. Rev. 2015, 115(24), 13165.
2. [2]
  Y. Fang, J. Shi, J. Liang, D. Ma, H. Wang, Nat. Commun. 2025, 16(1), 1058.
3. [3]
  S. Panja, D.J. Adams, Chem. Soc. Rev. 2021, 50(8), 5165.
4. [4]
  L. Gu, X. Sun, J. Pan, D. Liu, L. Huang, Y. Yu, B. Yu, H. Cong, Biomaterials 2025, 323, 123432.
5. [5]
  Y.S. Zhang, A. Khademhosseini, Science 2017, 356(6337), eaaf3627.
6. [6]
  W.E. Hennink, C.F. Van Nostrum, Adv. Drug Delivery Rev. 2012, 64, 223.
7. [7]
  X. Xu, V.V. Jerca, R. Hoogenboom, Mater. Horiz. 2021, 8(4), 1173.
8. [8]
  G. Stojkov, Z. Niyazov, F. Picchioni, K. B. Ranjita, Gels 2021, 7(4), 255.
9. [9]
  Y. Liu, Z. Guo, Mater. Today Phys. 2024, 43, 101397.
10. [10]
  B. Wang, W. Xu, Z. Yang, Y. Wu, F. Pi, Macromol. Rapid Commun. 2022, 43(6), 2100785.
11. [11]
  D. Keller, J. Hermanns, Chem. Teach. Int. 2023, 5(1), 61.
12. [12]
  J.Q. Xu, X.G. Zhu, J.H. Zhao, G.X. Ling, P. Zhang, Adv. Colloid Interface Sci. 2023, 321, 103000.
13. [13]
  T. Curk, J. Dobnikar, D. Frenkel, Soft Matter 2016, 12(1), 35.
14. [14]
  R.J. Dong, P. Yan, Y. Su, X.Y. Zhu, Biomater. Sci. 2015, 3(7), 937.
15. [15]
  H. Arakawa, K. Takeda, S.L. Higashi, A. Shibata, Y. Kitamura, M. Lkeda, Polym. J. 2020, 52(8), 923.
16. [16]
  G. Kocak, C. Tuncer, V. Bütün, Polym. J. 2017, 8(1), 144.
17. [17]
  H. Kojima, Polym. J. 2018, 50(6), 411.
18. [18]
19. [19]
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