Citation: Jiaxi Xu, Yuan Ma. Stable Conformation of Several Common Aromatic Compounds[J]. University Chemistry, ;2025, 40(12): 183-186. doi: 10.12461/PKU.DXHX202508007 shu

Stable Conformation of Several Common Aromatic Compounds

Jiaxi Xu ^1,, ,
Yuan Ma ²

1.
College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China;
2.
Department of Chemistry, Tsinghua University, Beijing 100084, China

Corresponding author: Jiaxi Xu, jxxu@mail.buct.edu.cn
Received Date: 5 August 2025
Revised Date: 21 October 2025

The stable conformations of aromatic compounds constitute fundamental contents in teaching organic chemistry. They play a crucial role to discuss and to identify acidity/basicity and reactive activity in the aromatic electrophilic substitution of these compounds. Current textbooks inadequately explain the variation in stable conformations of different aromatic compounds and their underlying causes. This study systematically examines several representative aromatic compounds, including phenol, anisole, aniline, and trifluoromethylbenzene, by analyzing the relative strengths of their n-π₆⁶ conjugation and n-σ^* hyperconjugation, as well as the involvement of hydrogen-bonding interactions. Through comprehensive evaluation of these electronic effects and intermolecular interactions, we elucidate the formations preferences and rationale their formation origins in these aromatic systems.
- Phenol,
- Aniline,
- Anisole,
- (Trifluoromethoxy) benzene,
- Stable conformation,
- Hyperconjugation effect
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