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Citation: Ruikang Su, Muyan Bai, Zhiqing Liu, Fang Fang, Yuena Yu. Wittig反应与可见光氧化还原催化融合构建烯烃[J]. University Chemistry, ;2026, 41(8): 370-379. doi: 10.12461/PKU.DXHX202507075 shu

Wittig反应与可见光氧化还原催化融合构建烯烃

Department of Chemistry, Southern University of Science and Technology, Shenzhen 518055, Guangdong Province, China

Corresponding author: Fang Fang, Yuena Yu,
Received Date: 21 July 2025
Accepted Date: 8 September 2025

将经典的Wittig反应和可见光氧化还原催化前沿成果融合，以叔丁氧羰基脯氨酸、苯甲醛和乙烯基三苯基溴化膦为原料，以1,2,3,5-四(咔唑-9-基)-4,6-二氰基苯(4CzIPN)为光敏剂，通过可见光诱导引发的自由基-极性交叉机理，实现了分子的快速组装并选择性地获得E-或Z-烯烃立体异构体。实验操作涵盖可见光催化合成、无水无氧操作、核磁共振分析、薄层色谱以及自动柱层析纯化等，并对反应机理进行探究。本文以基础理论知识为切入点，将前沿技术、方法和绿色化学理念转化为教学实践，致力于提升学生综合科研素养。
- Wittig reaction,
- Visible light photoredox catalysis,
- Radical-polar crossover reaction,
- Olefins
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