Citation: Fumei Yang, Yuxin Bai, Zhen Zhang, Jia Luo, Yongchen Gou, Mingli Peng, Guang Jia, Haiming Fan. The Rising Path of MPI: A New Star in Medical Imaging Innovation[J]. University Chemistry, ;2026, 41(4): 289-296. doi: 10.12461/PKU.DXHX202507006 shu

The Rising Path of MPI: A New Star in Medical Imaging Innovation

Fumei Yang ¹ ,
Yuxin Bai ¹ ,
Zhen Zhang ¹ ,
Jia Luo ¹ ,
Yongchen Gou ² ,
Mingli Peng ^1,, ,
Guang Jia ^2,, ,
Haiming Fan ¹

1.
National Chemistry Experimental Teaching Demonstration Center, College of Chemistry and Materials science, Northwest University, Xi'an 710127, Shaanxi Province, China;
2.
School of Computer Science and Technology, Xidian University, Xi'an 710126, Shaanxi Province, China

Corresponding author: Mingli Peng, Guang Jia,
Received Date: 3 July 2025
Accepted Date: 27 August 2025

Magnetic Particle Imaging (MPI), an emerging molecular imaging technology, has demonstrated remarkable potential in preclinical medical applications, particularly in stem cell tracking and immunotherapy. Distinguished by its unique imaging principles, high spatial sensitivity, absence of ionizing radiation, and excellent temporal resolution, MPI represents a significant advancement in biomedical imaging. This article presents a first-person perspective on MPI's developmental trajectory, fundamental technical principles, progress in preclinical applications, as well as current challenges and future prospects. Our objective is to provide readers with a comprehensive picture of this rising star's critical value and promising developmental in the medical field.
- Magnetic Particle Imaging,
- Molecular Imaging,
- Preclinical Applications,
- Popularization of science
1. [1]
  L.C. Wu, Y. Zhang, G. Steinberg, X. Sun, F. Sun, Y. Sun, Y. Zhang, Y. Xie, H. Wang, W. Lin, et al. Am. J. Neuroradiol. 2019, 40 (2), 206.
2. [2]
  B. Gleich, J. Weizenecker. Nature 2005, 435 (7046), 1214.
3. [3]
  L. Zhang, J. Li, J. Du, X. Wang, Y. Li, Z. Zhang, H. Zhang. J. Magn. Magn. Mater. 2024, 594, 171894.
4. [4]
  J. Weizenecker, B. Gleich, J. Rahmer, H. Dahnke, J. Borgert. Phys. Med. Biol. 2009, 54 (5), L1.
5. [5]
  T.F. Sattel, T. Knopp, S. Biederer, B. Gleich, J. Weizenecker, J. Rahmer, J. Borgert. J. Phys. D: Appl. Phys. 2009, 42 (2), 022001.
6. [6]
  N. Talebloo, M. Gudi, N. Robertson, P. Wang. J. Magn. Reson. Imaging 2020, 51 (6), 1659.
7. [7]
  M. Graeser, F. Thieben, P. Szwargulski, T. Knopp, M.G. Kaul, K.M. Krishnan, H. Ittrich, G. Adam, T.M. Buzug. Nat. Commun. 2019, 10 (1), 1.
8. [8]
  H. Hui, J. Liu, H. Zhang, Y. Li, Z. Wang, X. Li. IEEE Magn. Lett. 2023, 14, 1.
9. [9]
  T.A. Le, M.P. Bui, Y. Hadadian, J. Tang, E.Y. Yu, R.M. Ferguson, K.M. Krishnan, S.M. Chowdhury. Med. Imaging 2024, 43 (12), 1.
10. [10]
  J.W.M. Bulte, Adv. Drug Deliv. Rev. 2019, 138, 293.
11. [11]
12. [12]
  R.M. Ferguson, K.R. Minard, A.P. Khandhar, K.M. Krishnan. J. Magn. Magn. Mater. 2009, 321 (10), 1548.
13. [13]
  Q. Wang, X. Ma, H. Liao, Z. Wang, F. Li, M. Tian, Y. Zhang. ACS Nano 2020, 14 (2), 2053.
14. [14]
  G. Song, M. Kenney, Y.-S. Chen, X. Zheng, Y. Deng, L. Chen, S.X. Wang, S.J. Gambhir, Z. Cheng, F. Zhang. Nat. Biomed. Eng. 2020, 4 (3), 325.
15. [15]
  G. Guan, G. Shi, H. Liu, Y. Wang, Z. Li, X. Jiang, Y. Chen, L. Wang, Y. Zhang. Adv. Mater. 2024, 36 (49), 2409117.
16. [16]
  C. Huang, Q. Li, Q. Wang, Y. Zhang, X. Li, Z. Wang, L. Zhang. Adv. Mater. 2025, 37, 2413968.
17. [17]
  X. Xie, J. Zhai, X. Zhou, Y. Liu, Y. Zhang, H. Zhang, L. Wang. Adv. Mater. 2024, 36 (17), e2306450.
18. [18]
19. [19]
  S. Biederer, T. Knopp, T.F. Sattel, M. Ludtke-Buzug, B. Gleich, J. Weizenecker, J. Borgert, T.M. Buzug. J. Phys. D: Appl. Phys. 2009, 42 (20), 205007.
20. [20]
  J. Rahmer, J. Weizenecker, B. Gleich, J. Borgert. IEEE Trans. Med. Imaging 2012, 31 (6), 1289.
21. [21]
  A.C. Velazquez-Albino, E.D. Imhoff, C.M. Rinaldi-Ramos. Sci. Adv. 2025, 11 (2), eado7356.
22. [22]
  V. Tabar, H. Sarva, A.M. Lozano, A. Lang, P. Starr, M. Hallett, K. Baker, A. Espay, R. Ullman, R. Alterman. Nature 2025, 641, 978.
23. [23]
  Q. Wang, X. Ma, H. Liao, Z. Wang, F. Li, M. Tian, Y. Zhang. ACS Nano 2020, 14 (2), 2053.
24. [24]
  B. Zheng, M.P. von der Ohe, P.C.N. Rensen, R.M. Schiffelers, J. Prakash. Theranostics 2016, 6 (3), 291.
25. [25]
  A. Rivera-Rodriguez, L.B. Hoang-Minh, A. Chiu-Lam, M.S. Wacker, C. Rinaldi-Ramos. Nanotheranostics 2021, 5 (4), 431.
26. [26]
  O.C. Sehl, Y. Yang, P. Chandrasekharan, Z.W. Tay, E.Y. Yu, D.W. Hensley, X.Y. Zhou, B. Zheng, C. Rinaldi-Ramos, S. Conolly. Mol. Imaging Biol. 2024, 27 (1), 1.
27. [27]
  E.Y. Yu, P. Chandrasekharan, R. Berzon, Z.W. Tay, X.Y. Zhou, A.P. Khandhar, R.M. Ferguson, S.J. Kemp, B. Zheng, K.M. Krishnan, et al. ACS Nano 2017, 11 (12), 12067.
28. [28]
  J. Kydd, R. Jadia, P. Velpurisiva, A. Gad, S. Paliwal, P. Rai. Pharmaceutics 2017, 9 (4), 46.
29. [29]
  Z.W. Tay, P. Chandrasekharan, A. Chiu-Lam, D.W. Hensley, R. Dhavalikar, B. Zheng, E.Y. Yu, P. Goodwill, C. Rinaldi, S. Conolly. ACS Nano 2018, 12 (4), 3699.
30. [30]
  A.M. Rauwerdink, E.W. Hansen, J.B. Weaver. Phys. Med. Biol. 2009, 54 (19), L51.
31. [31]
  H. Carlton, M. Salimi, K.M. Krishnan, S.M. Chowdhury, E.Y. Yu. Adv. Funct. Mater. 2025, 35 (2), 2412321.
32. [32]
  E. Mattingly, M. Śliwiak, E. Mason, P. Goodwill, S. Conolly. Phys. Med. Biol. 2025, 70 (1), 015019.
33. [33]
  B. Zhang, H. Zhang, P. Gao, Y. Li, Z. Wang, X. Li. Instrum. Meas. 2024, 73, 1.
34. [34]
  Q. Wang, Z. Zhang, L. Li, F. Schrank, Y. Zeng, P. Guo, H. Radermacher, V. Schulz, S. Zhu. Med. Imaging 2024, 44 (4), 1.
35. [35]
  L. Fan, C. Wang, Y. Tian, Z. Li, X. Jiang, Y. Chen, L. Wang, Y. Zhang. Nano Today 2025, 62, 102706.
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