Abstract: In accordance with the “Guidelines for Ideological and Political Education in Higher Education Institutions” and aligned with the physical chemistry curriculum requirements for chemistry majors, this study examines the derivation and application of the Nernst equation as a representative case. We implement a blended teaching model combining online and offline components through 5E instructional design, integrating ideological-political elements via three dimensions: cultivation of scientific historical perspectives, development of innovative thinking, and incorporation of social responsibility. By exploring the Nernst equation’s scientific history, methodological significance, and contemporary applications in energy technologies, our approach facilitates students’ professional knowledge acquisition while fostering proper values, scientific spirit, and capabilities for independent inquiry and knowledge transfer. Distinct from previous research, this work innovatively merges ideological-political education with the physical chemistry knowledge system, preserving academic rigor while achieving value-oriented educational objectives. The study provides an exemplary and practical reference for implementing ideological-political education in chemistry-related curricula, supporting higher education’s tripartite mission of value cultivation, knowledge dissemination, and competency development.