基于超分子组装的纳米递药系统的构建与表征—

引用本文: 段智然, 曲海晶, 薛向东. 基于超分子组装的纳米递药系统的构建与表征——超分子化学实验的教学实践[J]. 大学化学, 2026, 41(7): 239-249. doi: 10.12461/PKU.DXHX202505021 shu

Citation: Zhiran Duan, Haijing Qu, Xiangdong Xue. Construction and characterization of supramolecular assembly-based nanodrug delivery systems: a teaching practice in supramolecular chemistry experiment[J]. University Chemistry, 2026, 41(7): 239-249. doi: 10.12461/PKU.DXHX202505021 shu

基于超分子组装的纳米递药系统的构建与表征——超分子化学实验的教学实践

上海交通大学药学院, 上海 200240

通讯作者: 薛向东,Email:xuexd@sjtu.edu.cn

基金项目:
上海交通大学2025年度实验教学改革项目"高端制剂驱动的药剂学实验课程创新建设

摘要: 在深化新医科建设，培养交叉学科高素质人才的战略背景的指引下，本文构建了一种面向药物递送前沿的综合教学实验，将超分子化学的理论知识与纳米医学实践深度融合。研究以二氢卟酚e6和替莫唑胺为模型药物，通过超声辅助超分子组装技术制备纳米递药体系，系统探究不同药物比例对纳米递药体系性能的影响。本实验利用聚集诱导荧光淬灭现象确定了超分子组装的成功进行，使用动态光散射表征了纳米递药系统的流体动力学粒径与Zeta电位，并通过紫外分光光度法测定药物包封率。本实验立足于解决当前常见纳米递药系统载药量低、辅料使用过多带来的潜在风险，采用无需辅料的超分子组装技术制备纯药物纳米颗粒。该实验操作简单，原理明确深入，且具有良好的可拓展性，有助于使学生掌握纳米递药系统研发核心技能，同时加深学生对纳米递药系统的理解，为培养“懂原理、擅创新、重实践”的新医科复合型人才提供了可推广范式。

关键词:

English

Construction and characterization of supramolecular assembly-based nanodrug delivery systems: a teaching practice in supramolecular chemistry experiment

School of Pharmaceutical Science, Shanghai Jiao Tong University, Shanghai 200240, China

Corresponding author: Xiangdong Xue, xuexd@sjtu.edu.cn

Received Date: 08 May 2025
Revised Date: 27 August 2025
Available Online: 23 September 2025

Abstract: Guided by the strategic initiative to advance “New Medical Science” education and cultivate high-quality interdisciplinary talents, this study developed an integrated teaching experiment that bridges cutting-edge drug delivery research with practical nanomedicine applications. The experiment synergistically combines theoretical knowledge of supramolecular chemistry with hands-on practice, employing chlorin e6 and temozolomide as model drugs to prepare a nano-drug delivery system through ultrasound-assisted supramolecular assembly. We systematically examined how varying drug ratios affect the system’s performance. Successful supramolecular assembly was verified by aggregation-induced fluorescence quenching, while dynamic light scattering (DLS) characterized the system’s hydrodynamic size and zeta potential. Drug encapsulation efficiency was quantified using ultraviolet spectrophotometry. This innovative approach overcomes limitations of conventional nano-drug delivery systems, such as low drug-loading capacity and excipient-related safety concerns, by producing pure drug nanoparticles through excipient-free supramolecular assembly. With its straightforward protocol, well-defined scientific principles, and excellent scalability, this experiment effectively equips students with core competencies in nanodrug delivery system development while enhancing their conceptual understanding. It serves as an exemplary model for training interdisciplinary “New Medical Science” professionals who thoroughly comprehend fundamental principles, demonstrate innovation capabilities, and value practical application.

Key words:

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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

基于超分子组装的纳米递药系统的构建与表征——超分子化学实验的教学实践

通讯作者: 薛向东,Email:xuexd@sjtu.edu.cn

English

Construction and characterization of supramolecular assembly-based nanodrug delivery systems: a teaching practice in supramolecular chemistry experiment

Corresponding author: Xiangdong Xue, xuexd@sjtu.edu.cn

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

基于超分子组装的纳米递药系统的构建与表征——超分子化学实验的教学实践

通讯作者: 薛向东,Email:xuexd@sjtu.edu.cn

English

Construction and characterization of supramolecular assembly-based nanodrug delivery systems: a teaching practice in supramolecular chemistry experiment

Corresponding author: Xiangdong Xue, xuexd@sjtu.edu.cn

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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通讯作者: 陈斌, bchen63@163.com

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