基于香豆素查耳酮衍生物合成的药学本科专业有机化学实验三阶递进式教学改革与实践

虎春艳 王葳 毛泽伟 张美 张磊 林玉萍

引用本文: 虎春艳, 王葳, 毛泽伟, 张美, 张磊, 林玉萍. 基于香豆素查耳酮衍生物合成的药学本科专业有机化学实验三阶递进式教学改革与实践[J]. 大学化学, 2026, 41(7): 282-289. doi: 10.12461/PKU.DXHX202505011 shu
Citation:  Chunyan Hu,  Wei Wang,  Zewei Mao,  Mei Zhang,  Lei Zhang,  Yuping Lin. Three-stage progressive teaching reform and practice in organic chemistry experiments for pharmacy undergraduates: synthesis of coumarin-chalcone derivatives[J]. University Chemistry, 2026, 41(7): 282-289. doi: 10.12461/PKU.DXHX202505011 shu

基于香豆素查耳酮衍生物合成的药学本科专业有机化学实验三阶递进式教学改革与实践

    通讯作者: 林玉萍,Email:linyuping1221@163.com
  • 基金项目:

    云南省教育厅教改项目(GJ2024036)

    云南中医药大学本科教育教学改革项目(JG202310,JJ20160101)

    云南中医药大学本科课程思政教改项目(KCSZJG2425)

摘要: 基于新医科建设对创新型药学人才培养的要求,针对药学专业传统有机化学实验教学中以验证性实验为主,学生被动完成实验操作,缺乏对实验设计、反应机理及药物研发逻辑的系统性理解等问题,本研究构建了“理论奠基-创新设计-综合实践”三阶递进式项目化教学体系。以药学领域备受关注的香豆素查耳酮衍生物的创新合成为载体,通过理论教学与实验探索联动、合成方案创新设计、跨课程综合表征实践的系统训练,培养学生从分子设计到结构表征的系统科研思维和药学学科核心素养,为新医科背景下药学专业实验教学改革提供了创新范式。

English

    1. [1]

      N.K. Sahu, S.S. Balbhadra, J. Choudhary, D.v. Kohli. Med. Chem. 2012, 19, 209.N.K. Sahu, S.S. Balbhadra, J. Choudhary, D.v. Kohli. Med. Chem. 2012, 19, 209.

    2. [2]

      K.N. Venugopala, V. Rashmi, B. Odhav. BioMed. Res. Int. 2013, 1, 963248.K.N. Venugopala, V. Rashmi, B. Odhav. BioMed. Res. Int. 2013, 1, 963248.

    3. [3]

      A. Detsi, C. Kontogiorgis, D. Hadjipavlou-Litina, Expert Opin. Ther. Pat. 2017, 27, 1201.A. Detsi, C. Kontogiorgis, D. Hadjipavlou-Litina, Expert Opin. Ther. Pat. 2017, 27, 1201.

    4. [4]

      P. Singh, A. Anand, V. Kumar, Eur. J. Med. Chem. 2014, 85, 758.P. Singh, A. Anand, V. Kumar, Eur. J. Med. Chem. 2014, 85, 758.

    5. [5]

      虎春艳, 郑喜, 林玉萍, 王秀丽, 毛泽伟. 化学通报, 2017, 80(4), 396.

    6. [6]

      K. Kasperkiewicz, M.B. Ponczek, J. Owczarek, P. Guga, E. Budzisz, Molecules 2020, 25(6), 1465.K. Kasperkiewicz, M.B. Ponczek, J. Owczarek, P. Guga, E. Budzisz, Molecules 2020, 25(6), 1465.

    7. [7]

      R. Pingaew, A. Saekee, P. Mandi, C. Nantasenamat, S. Prachayasittikul, S. Ruchirawat, V. Prachayasittikul, Eur. J. Med. Chem. 2014, 85, 65.R. Pingaew, A. Saekee, P. Mandi, C. Nantasenamat, S. Prachayasittikul, S. Ruchirawat, V. Prachayasittikul, Eur. J. Med. Chem. 2014, 85, 65.

    8. [8]

      S. Vazquez-Rodriguez, R.L. López, M.J. Matos, G. Armesto-Quintas, S. Serra, E. Uriarte, L. Santana, F. Borges, A.M. Crego, Y. Santos, Bio. Med. Chem. 2015, 23, 7045.S. Vazquez-Rodriguez, R.L. López, M.J. Matos, G. Armesto-Quintas, S. Serra, E. Uriarte, L. Santana, F. Borges, A.M. Crego, Y. Santos, Bio. Med. Chem. 2015, 23, 7045.

    9. [9]

      K.V. Sashidhara, K.B. Rao, P. Kushwaha, R.K. Modukuri, P. Singh, I. Soni, P.K. Shukla, S. Chopra, M. Pasupuleti, ACS Med. Chem. Lett. 2015, 6, 809.K.V. Sashidhara, K.B. Rao, P. Kushwaha, R.K. Modukuri, P. Singh, I. Soni, P.K. Shukla, S. Chopra, M. Pasupuleti, ACS Med. Chem. Lett. 2015, 6, 809.

    10. [10]

      S. Emami, S. Dadashpour, Eur. J. Med. Chem. 2015, 102, 611.S. Emami, S. Dadashpour, Eur. J. Med. Chem. 2015, 102, 611.

    11. [11]

      Y. Wang, W. Zhang, J. Dong, J. Gao, Bioorg. Chem. 2020, 95, 103530.Y. Wang, W. Zhang, J. Dong, J. Gao, Bioorg. Chem. 2020, 95, 103530.

    12. [12]

      沈云红, 陈红洁, 毛泽伟, 黄正晓, 虎春艳. 中国药科大学学报, 2023, 54(5), 564.

    13. [13]

      N. Rohman, B. Ardiansah, T. Wukirsari, Z. Judeh, Molecules 2024, 29(5), 1026.N. Rohman, B. Ardiansah, T. Wukirsari, Z. Judeh, Molecules 2024, 29(5), 1026.

    14. [14]

      M.M. Barger, T. Perez, D.A. Canelas, L. Linnenbrink-Garcia, Learn. Individ. Differ. 2018, 63, 89.M.M. Barger, T. Perez, D.A. Canelas, L. Linnenbrink-Garcia, Learn. Individ. Differ. 2018, 63, 89.

    15. [15]

      R.D. Arnold, J.P. Wade, Procedia Comput. Sci. 2015, 44, 669.R.D. Arnold, J.P. Wade, Procedia Comput. Sci. 2015, 44, 669.

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  • 发布日期:  2025-10-17
  • 收稿日期:  2025-05-08
  • 修回日期:  2025-07-31
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