Citation: Chengshan Yuan, Xiaolong Li, Xiuping Yang, Xiangfeng Shao, Zitong Liu, Xiaolei Wang, Yongwen Shen. Standardized Operational Guidelines for Mixed-Solvent Recrystallization in Organic Chemistry Experiment[J]. University Chemistry, ;2025, 40(5): 122-127. doi: 10.12461/PKU.DXHX202504073 shu

Standardized Operational Guidelines for Mixed-Solvent Recrystallization in Organic Chemistry Experiment

College of Chemistry and Chemical Engineering, National Demonstration Center for Experimental Chemistry (Lanzhou University), State Key Laboratory of Applied Chemistry, Lanzhou University, Lanzhou 730000, China

Corresponding author: Chengshan Yuan, yuancs@lzu.edu.cn
Received Date: 28 April 2025
Revised Date: 8 May 2025

Mixed-solvent recrystallization is a commonly used and highly selective purification method. However, systematic operational guidelines are still lacking in current teaching, and students often encounter issues such as inappropriate solvent selection or improper techniques, resulting in failed crystallization or low purity. This paper outlines the basic principles and procedures of mixed-solvent recrystallization, clarifies key steps including solvent selection, decolorization, hot filtration, and crystallization induction, and proposes practical guidelines. These recommendations are feasible and widely applicable, offering a reference for standardizing laboratory instruction.
- Organic chemistry experiment,
- Recrystallization,
- Mixed solvent,
- Standardized operational guideline
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