Home

Citation: Ruoyu Cao, Jiaxin Chen, Jiaen Hu, Youting Zhai, Jiacong Fu, Lifen Hou, Xuebin Yan, Yanyang Li, Kai Li, Shuangquan Zang. Interactive Digital Experiment for Organic Synthesis: Designing Process and Case Presentation[J]. University Chemistry, ;2026, 41(1): 406-412. doi: 10.12461/PKU.DXHX202504022 shu

Interactive Digital Experiment for Organic Synthesis: Designing Process and Case Presentation

College of Chemistry, Zhengzhou University, Zhengzhou 450001, China

Corresponding author: Yanyang Li, Kai Li,
Received Date: 8 April 2025
Revised Date: 23 July 2025

In this work, we developed an interactive digital teaching model for experimental chemistry education. The approach employs digital technologies to perform retrosynthetic analysis of target compounds while evaluating different synthetic routes based on cost, safety, and yield parameters to identify optimal pathways for teaching purposes. Each route is systematically optimized to address potential operational challenges, with multiple troubleshooting solutions incorporated. The final output is presented as an interactive video-based digital experiment. Within this framework, instructors can utilize digital tools to design experimental pathways and generate randomized events, thereby guiding students through problem identification, solution development, and experimental completion. This interactive teaching paradigm represents a significant advancement over traditional linear virtual experiments, offering enhanced flexibility, personalization, real-time feedback, and improved differentiation capabilities. The methodology demonstrates considerable potential for broader application in experimental chemistry education.
- Interactive,
- Digitization,
- Organic synthesis,
- Interactive video
1. [1]
2. [2]
3. [3]
  Mikulak-Klucznik, B.; Gołębiowska, P.; Bayly, A. A.; Popik, O.; Klucznik, T.; Szymkuć, S.; Gajewska, E. P.; Dittwald, P.; Staszewska-Krajewska, O.; Beker, W.; et al. Nature 2020, 588, 83.
4. [4]
  Klucznik, T.; Mikulak-Klucznik, B.; McCormack, M. P.; Lima, H.; Szymkuć, S.; Bhowmick, M.; Molga, K.; Zhou, Y.; Rickershauser, L.; Gajewska, E. P.; et al. Chem 2018, 4 (3), 522.
5. [5]
  Ishida, S.; Terayama, K.; Kojima, R.; Takasu, K.; Okuno, Y. J. Chem. Inf. Model. 2022, 62 (6), 1357.
6. [6]
  Genheden, S.; Thakkar, A.; Chadimová, V.; Reymond, J.-L.; Engkvist, O.; Bjerrum, E. J. Cheminform. 2020, 12 (1), 70.
7. [7]
  Zeng, T.; Jin, Z.; Zheng, S.; Yu, T.; Wu, R. JACS Au 2024, 4 (7), 2492.
8. [8]
1. [1]
  Cuiyuan Liang , Xinyu Zhang , Mei Zhang , Dianpeng Qi . 有机化学教学数字化智能化改造. University Chemistry, 2026, 41(8): 40-46. doi: 10.12461/PKU.DXHX202507053
2. [2]
  Kai Ye , Lizhong Zhang , Mingyu Zhang , Qinxiong Wu , Kui Wang , Qi Wang . Digital Experiment for the Determination of Liquid Saturated Vapor Pressure. University Chemistry, 2026, 41(1): 227-243. doi: 10.12461/PKU.DXHX202503107
3. [3]
  Xiaoyan Wang , Yan Qi , Lin Tang , Shuwen Wang , Huiling Wen , Hongtao Gao . Improvement of the Quality Construction of Basic Chemistry Experimental Teaching Center under the Background of Education Digitization. University Chemistry, 2024, 39(7): 40-48. doi: 10.12461/PKU.DXHX202404124
4. [4]
  Yan Su , Yuzhen Pan , Fuping Tian , Xiuyun Wang , Tieqi Xu , Yongce Zhang , Miao Cui , Wenfeng Jiang . Construction and Practice of the National Chemical Experimental Teaching Demonstration Center under the Background of Digital Education. University Chemistry, 2024, 39(7): 218-222. doi: 10.12461/PKU.DXHX202406001
5. [5]
  Dengke Ma . Application of Integrating Fundamental Knowledge and Cutting-Edge Developments in the Teaching of Organic Synthesis: Taking the Asymmetric Meinwald Rearrangement as an Example. University Chemistry, 2026, 41(4): 67-74. doi: 10.12461/PKU.DXHX202502112
6. [6]
  Wenwen Ma , Lian Kong , Jinyang Chu , Li Ma , Ziqing Ma , Heyu Cheng , Xinyuan Li , Zhan Yu , Zhen Zhao . Digitalization-Driven Olefin Production: Digital Design of Catalysts for CO₂-Assisted Oxidation Dehydrogenation of Ethane to Ethylene. University Chemistry, 2026, 41(1): 363-372. doi: 10.12461/PKU.DXHX202506055
7. [7]
  Juan Hou . Reflection on the Innovation and Practice of Course Ideological and Political Education Teaching Design under the Digitalization Context: A Case Study of Analytical Chemistry Course. University Chemistry, 2026, 41(4): 90-97. doi: 10.12461/PKU.DXHX202502038
8. [8]
  Haofan Niu , Yuhan Wu , Xinran Li , Longmei Li , Dong Wang , Yongce Zhang , Fengyu Liu , Wei Bai . 自驱动固体酸催化乙酸苄酯的合成. University Chemistry, 2026, 41(1): 1-8. doi: 10.12461/PKU.DXHX202505049
9. [9]
  Bin Wang , Chuanli Qin , Naiying Fan , Zhibin Li , Zhibiao Zhu , Jiancong Liu , Shaoping Sun . Construction and Practice of Digital Platform and Teaching Resources of Chemistry Experimental Teaching Center: A Case Study of Provincial Demonstration Center for Experimental Chemistry Education (Heilongjiang University). University Chemistry, 2024, 39(7): 193-199. doi: 10.12461/PKU.DXHX202405116
10. [10]
  Fengxiao Wang , Zhiwei Miao , Yaofeng Yuan . 有机磷化学与化学教学. University Chemistry, 2025, 40(8): 158-168. doi: 10.12461/PKU.DXHX202410077
11. [11]
  Yongjian Zhang , Fangling Gao , Hong Yan , Keyin Ye . Electrochemical Transformation of Organosulfur Compounds. University Chemistry, 2025, 40(5): 311-317. doi: 10.12461/PKU.DXHX202407035
12. [12]
  Shiyan Cheng , Yonghong Ruan , Lei Gong , Yumei Lin . Research Advances in Friedel-Crafts Alkylation Reaction. University Chemistry, 2024, 39(10): 408-415. doi: 10.12461/PKU.DXHX202403024
13. [13]
  Aidang Lu , Yunting Liu , Yanjun Jiang . Comprehensive Organic Chemistry Experiment: Synthesis and Characterization of Triazolopyrimidine Compounds. University Chemistry, 2024, 39(8): 241-246. doi: 10.3866/PKU.DXHX202401029
14. [14]
  Yinuo Wang , Ziyu Liu , Hongxia Tan , Jun Tong , Dazhen Xu . Synthesis of Bromobenzoxazine: Introduce a Comprehensive Organic Chemistry Experiment Transformed from Undergraduate Research Innovation. University Chemistry, 2025, 40(10): 208-216. doi: 10.12461/PKU.DXHX202411077
15. [15]
  Shuhui Li , Rongxiuyuan Huang , Yingming Pan . Electrochemical Synthesis of 2,5-Diphenyl-1,3,4-Oxadiazole: A Recommended Comprehensive Organic Chemistry Experiment. University Chemistry, 2025, 40(5): 357-365. doi: 10.12461/PKU.DXHX202407028
16. [16]
  Yinuo Wang , Yichen Gan , Keyu Li , Dazhen Xu . Synthesis of 2-(4-Chlorobenzylidene) malononitrile via a self-made continuous flow reactor: a proposed comprehensive chemistry experiment. University Chemistry, 2026, 41(7): 319-325. doi: 10.12461/PKU.DXHX202506036
17. [17]
  Baitong Wei , Rongxiu Zhu , Zhenghu Xu . 双环[1.1.0]丁烷合成策略的研究进展. University Chemistry, 2026, 41(9): 162-172. doi: 10.12461/PKU.DXHX202508027
18. [18]
  Yifei Li , Xuexin Chen , Sihan Liu , Shiyi Chen , Ling Pan . Design and Application of Chemical Analysis Platform Based on Intelligent Integration of Big Data and Deep Learning Algorithm in Undergraduate Experimental Teaching. University Chemistry, 2026, 41(1): 169-178. doi: 10.12461/PKU.DXHX202504098
19. [19]
  Songmei Ma , Ying Zhang , Gang Liu , Wenlong Xu . Comprehensive Experiment Teaching Exploration and Practice in Polymeric Materials Integrating Research-Driven Learning, Creativity-Enhanced Competency, and Science-Education Synergy: A Case Study of Machine Learning-Assisted Intelligent Handwriting Recognition System. University Chemistry, 2026, 41(1): 289-297. doi: 10.12461/PKU.DXHX202509083
20. [20]
  Wentao Gan , Daxin Liang , Minghui Guo . Practical Exploration of the “Double Carbon” Talent Training Model in Forestry Engineering Based on the Virtual Teaching and Research Platform. University Chemistry, 2026, 41(4): 75-79. doi: 10.12461/PKU.DXHX202502021

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(869)
HTML views(133)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Address：Zhongguancun North First Street 2,100190 Beijing, PR China Tel: +86-010-82449177-888

DownLoad: Full-Size Img PowerPoint

Return