Citation: Pan Li, Huguo Shen, Cong Hua, Jinjie Fang, Xiangying Chi, Quan Jiang, Zichen Feng, Ye Kang, Bin Zheng. Synthesis and Characterization of an Aggregation-Induced Emission-Active Organic Cage Molecule: A Proposed Comprehensive Chemistry Experiment[J]. University Chemistry, ;2025, 40(11): 337-345. doi: 10.12461/PKU.DXHX202502083 shu

Synthesis and Characterization of an Aggregation-Induced Emission-Active Organic Cage Molecule: A Proposed Comprehensive Chemistry Experiment

School of Chemistry and Pharmaceutical Engineering, Hefei Normal University, Hefei 230601, China

Corresponding author: Pan Li, Bin Zheng,
Received Date: 17 February 2025
Revised Date: 21 July 2025

The incorporation of cutting-edge research achievements into undergraduate laboratory courses represents an effective approach to enhance students’ practical skills and innovative capacities. Herein, we report the rational design and synthesis of a tetraphenylethylene-based aggregation-induced emission (AIE)-active organic cage molecule (TPE-Cage) through dynamic covalent chemistry. Comprehensive characterization was performed using nuclear magnetic resonance (NMR) and matrix-assisted laser desorption/ionization time of flight mass (MALDI-TOF-MS) spectroscopy for structural verification, along with UV-Vis absorption and fluorescence spectroscopy to investigate its photophysical properties. This integrated experiment features innovative molecular architecture design, highly reproducible synthetic routes, and visually distinctive luminescent phenomena. As a well-designed teaching module, it effectively stimulates students’ scientific curiosity, bridges theoretical knowledge with practical implementation, and cultivates research-oriented thinking and innovation capabilities.
- Aggregation-induced emission,
- Cage-like compound,
- Dynamic covalent chemistry,
- Comprehensive chemistry experiment
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