Home

Citation: Yifan Xie, Liyun Yao, Ruolin Yang, Yuxing Cai, Yujie Jin, Ning Li. Exploration and Practice of Online and Offline Hybrid Teaching Mode in High-Performance Liquid Chromatography Experiment[J]. University Chemistry, ;2025, 40(11): 100-107. doi: 10.12461/PKU.DXHX202412133 shu

Exploration and Practice of Online and Offline Hybrid Teaching Mode in High-Performance Liquid Chromatography Experiment

Yifan Xie ^1,2 ,
Liyun Yao ^1,2,, ,
Ruolin Yang ² ,
Yuxing Cai ¹ ,
Yujie Jin ¹ ,
Ning Li ¹

1.
Basic Medical Experimental Teaching Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China;
2.
Medical Chemistry and Bioinformatics Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China

Corresponding author: Liyun Yao, yaoliyun517@163.com
Received Date: 30 December 2024
Revised Date: 14 February 2025

High-performance liquid chromatography (HPLC) is extensively utilized across various domains including life science research, clinical medical testing, drug development, and forensic identification. Improving the instructional effectiveness of HPLC instrument operation is crucial for nurturing highly competent and skilled medical technology professionals. However, challenges such as a high student-to-instrument ratio, limited availability of equipment, and the inability to conduct repeated operations have adversely impacted learning outcomes. To address these issues, this study integrates a blended online and offline teaching approach into the HPLC experimental curriculum by leveraging platforms such as Chaoxing Learning and virtual simulation experiments. This method optimizes teaching content across pre-class, in-class, and post-class phases. By employing task-driven strategies, facilitating online self-learning, conducting offline group practical exercises, and encouraging post-class summaries and knowledge expansion, the approach aims to comprehensively enhance student engagement and initiative. Empirical results demonstrate that this teaching model significantly improves instructional effectiveness and is favorably received by students.
- High-performance liquid chromatography,
- Online and offline hybrid teaching,
- Chaoxing learning platform,
- Virtual simulation experiment,
- Task-driven approach
1. [1]
2. [2]
3. [3]
4. [4]
5. [5]
6. [6]
7. [7]
8. [8]
9. [9]
10. [10]
11. [11]
12. [12]
1. [1]
  Haiyuan Wang , Xiaoning Jin , Yajing Sun , Zhen Zhang , Wentao Zhao , Yi Li . Practical Exploration of High-Performance Liquid Chromatography Experiment Teaching Reform Empowered by Artificial Intelligence. University Chemistry, 2026, 41(4): 45-51. doi: 10.12461/PKU.DXHX202505076
2. [2]
  Xi Bai , Weigang Fan , Fang Mi , Yuhua Ma , Guixin Li , Yinping Li , Gulimeikereyi Tuniyazi , Ming Guan . 讲好中国色谱故事：仪器分析课程思政教学案例设计——以高效液相色谱法为例. University Chemistry, 2026, 41(8): 119-129. doi: 10.12461/PKU.DXHX202507130
3. [3]
  Jianghua Qiu , Yang Chen , Yan Tang , Jing Xie , Xiongzhi Zhang . Reform and practice of inorganic chemistry experiment teaching for cultivating innovation capabilities. University Chemistry, 2026, 41(4): 208-215. doi: 10.12461/PKU.DXHX202507068
4. [4]
  Tianlong Zhang , Jiajun Zhou , Hongsheng Tang , Xiaohui Ning , Yan Li , Hua Li . Virtual Simulation Experiment for Laser-Induced Breakdown Spectroscopy (LIBS) Analysis. University Chemistry, 2024, 39(6): 295-302. doi: 10.3866/PKU.DXHX202312049
5. [5]
  Xinyu Xu , Changjin Ou , Chunxia Kong , Weiliang Tian , Huaming Wang , Haijiao Wang , Tao Tao . 近红外有机纳米粒子的合成及性质研究虚拟仿真实验. University Chemistry, 2026, 41(8): 350-362. doi: 10.12461/PKU.DXHX202507032
6. [6]
  Xiaoli Li , Zhongyi Li , Yanbing Wang . Exploration and Practice of Blended Learning in Organic Chemistry Based on Advanced and Basic Knowledge Points: A Case Study of the Animal Medicine Major. University Chemistry, 2026, 41(2): 131-139. doi: 10.12461/PKU.DXHX202501013
7. [7]
  Siming Bian , Sijie Luo , Junjie Ou . Application of van Deemter Equation in Instrumental Analysis Teaching: A New Type of Core-Shell Stationary Phase. University Chemistry, 2025, 40(3): 381-386. doi: 10.12461/PKU.DXHX202406087
8. [8]
  Gengjia Chen , Junjie Ou . Application of the van Deemter Equation in Instrumental Analysis Teaching: A Case of Organic Polymer Monolithic Columns. University Chemistry, 2025, 40(11): 362-368. doi: 10.12461/PKU.DXHX202502003
9. [9]
  Wanzhong Lang . 现代化学与人类文明课程思政教学实践与探索. University Chemistry, 2026, 41(8): 87-95. doi: 10.12461/PKU.DXHX202507126
10. [10]
  Tong Wang , Liangyu Hu , Shiqi Chen , Xinqiang Fu , Rui Wang , Kun Li , Shuangyan Huan . Determination of Benzenediol Isomers in Cosmetics Using High-Performance Liquid Chromatography Empowered by “Mathematical Separation”. University Chemistry, 2026, 41(1): 9-19. doi: 10.12461/PKU.DXHX202503128
11. [11]
  Xia Yin , Peng Yang , Feng Xu , Yan Zhao , Shuangyan Huan , Jingzhe Zhao , Gonglan Ye , Yingpeng Wu . Exploration and Practice of Ideological and Political Education in Inorganic Chemistry Experiment Course. University Chemistry, 2025, 40(7): 119-126. doi: 10.12461/PKU.DXHX202408093
12. [12]
  Fan Wu , Wenchang Tian , Jin Liu , Qiuting Zhang , YanHui Zhong , Zian Lin . Core-Shell Structured Covalent Organic Framework-Coated Silica Microspheres as Mixed-Mode Stationary Phase for High Performance Liquid Chromatography. University Chemistry, 2024, 39(11): 319-326. doi: 10.12461/PKU.DXHX202403031
13. [13]
  Shengyan Yang , Xiangzhen Meng , Xin Wang , Yang Zhang . Construction and Exploration of an Online-Offline Blended “Eight-Link” Teaching Method for Physical Chemistry Experiments Based on OBE Concept. University Chemistry, 2024, 39(11): 28-37. doi: 10.3866/PKU.DXHX202402019
14. [14]
  Tuerxun Jianaer , Wen Zhang , Abuduaihaiti Miriguli , Ruikang Tan . Design and practice of a blended teaching model for organic chemistry based on task-driven learning: a case study of “conjugated systems and conjugation effects”. University Chemistry, 2026, 41(7): 1-7. doi: 10.12461/PKU.DXHX202504009
15. [15]
  Wenwen Ma , Liyan Liu , Chengyang Yin , Hongdan Zhang , Lian Kong , Na Wei , Zhan Yu , Zhen Zhao . Exploration of the Online and Offline Mixed Teaching Mode of Specialized English for Chemistry Majors Based on the BOPPPS Model. University Chemistry, 2025, 40(9): 287-294. doi: 10.12461/PKU.DXHX202410026
16. [16]
  Peiyan Ma , Zheng Xie , Chen Wang . “元素周期表与元素性质的周期性变化”的线上线下混合式教学模式课程设计. University Chemistry, 2026, 41(8): 8-18. doi: 10.12461/PKU.DXHX202508015
17. [17]
  Qian Wu , Hongmei Lu . Practical task-driven flipped classroom teaching design for “advanced separation and analysis”. University Chemistry, 2026, 41(4): 165-172. doi: 10.12461/PKU.DXHX202504039
18. [18]
  Xiaojun Wu , Kai Hu , Faqiong Zhao . Laying the Groundwork for General Chemistry Experiment Teaching: Exploration and Summary of Assisting Experiment Preparatory Work through Online and Offline Integration. University Chemistry, 2024, 39(8): 23-27. doi: 10.3866/PKU.DXHX202312052
19. [19]
  Shuang Meng , Haixin Long , Zhou Zhou , Meizhu Rong . Inorganic Chemistry Curriculum Design and Implementation of Based on “Stepped-Task Driven + Multi-Dimensional Output” Model: A Case Study on Intermolecular Forces. University Chemistry, 2024, 39(3): 122-131. doi: 10.3866/PKU.DXHX202309008
20. [20]
  Zhiguang Xu , Xuan Xu , Qiong Luo , Ganquan Wang , Bin Peng . Reform and Practice of Online and Offline Blended Teaching in Structural Chemistry Course. University Chemistry, 2024, 39(6): 195-200. doi: 10.3866/PKU.DXHX202310112

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(1321)
HTML views(99)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Address：Zhongguancun North First Street 2,100190 Beijing, PR China Tel: +86-010-82449177-888

DownLoad: Full-Size Img PowerPoint

Return